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Details on Person Aggrecan degradation by MMP1,2,3,7,9,12,13

Class:Id	Reaction:3814821
_displayName	Aggrecan degradation by MMP1,2,3,7,9,12,13
_doRelease	TRUE
_timestamp	2013-09-05 11:53:28
authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:3814809] metalloendopeptidase activity of MMP1,2,3,7,9,12,13 [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:3814823] Jupe, S, 2013-07-08
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
input	[EntityWithAccessionedSequence:3814816] ACAN [extracellular region] [Sus scrofa]
isChimeric	TRUE
literatureReference	[LiteratureReference:3791275] Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins [LiteratureReference:3791303] The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B [LiteratureReference:3791297] Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain [LiteratureReference:3791253] Degradation of cartilage aggrecan by collagenase-3 (MMP-13) [LiteratureReference:2534002] MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
modified	[InstanceEdit:3814826] Jupe, S, 2013-07-08 [InstanceEdit:4093350] Jupe, S, 2013-08-14 [InstanceEdit:4265163] Jupe, S, 2013-08-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Aggrecan degradation by MMP1,2,3,7,9,12,13
output	[EntityWithAccessionedSequence:3814819] ACAN N-terminal fragment [extracellular region] [Sus scrofa] [EntityWithAccessionedSequence:3814807] ACAN C-terminal fragment [extracellular region] [Sus scrofa]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens [Species:49633] Sus scrofa
stableIdentifier	[StableIdentifier:4545344] R-NUL-3814821.2
summation	[Summation:3814810] Aggrecan (large aggregating proteoglycan, chondroitin sulfat...
(inferredFrom)	[Reaction:3791295] Aggrecan degradation by MMP1,2,3,7,9,12,13 [Homo sapiens]
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No pathways have been reviewed or authored by Aggrecan degradation by MMP1,2,3,7,9,12,13 (3814821)