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Details on Person HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1

Class:Id	Reaction:3814820
_displayName	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
_doRelease	TRUE
_timestamp	2013-09-05 11:48:30
authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:3828026] serine-type endopeptidase activity of BMP1, TLL1, TLL2, Cathepsin L1 [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:3814823] Jupe, S, 2013-07-08
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
input	[EntityWithAccessionedSequence:1011570] HSPG2(22-4391) [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3828012] BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan [LiteratureReference:3828007] Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
modified	[InstanceEdit:3814826] Jupe, S, 2013-07-08 [InstanceEdit:3827985] Jupe, S, 2013-07-09 [InstanceEdit:4093350] Jupe, S, 2013-08-14 [InstanceEdit:4210796] Jupe, S, 2013-08-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
output	[EntityWithAccessionedSequence:3827968] HSPG2(22-4196) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3827980] HSPG2(4197-4391) [extracellular region] [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545228] R-HSA-3814820.2
summation	[Summation:3814824] Endorepellin is the 85-kDa C-terminal domain V of HSPG2 (per...
(hasEvent)	[Pathway:1474228] Degradation of the extracellular matrix [Homo sapiens]
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No pathways have been reviewed or authored by HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (3814820)