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Details on Person UniProt:Q29011 ACAN
| Class:Id | ReferenceGeneProduct:3814808 |
|---|---|
| _chainChangeLog | chain:1- added on Sat February 7 2015;chain:4- added on Sat February 7 2015;chain:1-537 for 3814808 removed on Fri Feb 21 2025;chain:4-537 for 3814808 removed on Fri Feb 21 2025;signal peptide:1-16 for 3814808 added on Fri Feb 21 2025;chain:17-2434 for 3814808 added on Fri Feb 21 2025;chain:393-2434 for 3814808 added on Fri Feb 21 2025 |
| _displayName | UniProt:Q29011 ACAN |
| _timestamp | 2025-08-15 21:17:45 |
| chain | signal peptide:1-16 chain:17-2434 chain:393-2434 |
| checksum | 604FDC9CFBC50E6F |
| comment | FUNCTION This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.SUBUNIT Forms a complex (via covalent bonds) with MATN1; the interaction increases with age of the organism via an increase in occupancy of MATN1 binding sites (By similarity). Interacts with FBLN1 (By similarity). Interacts with COMP (By similarity).SUBCELLULAR LOCATION Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.PTM Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides.SIMILARITY Belongs to the aggrecan/versican proteoglycan family. |
| created | [InstanceEdit:3814806] Jupe, S, 2013-07-08 |
| description | recommendedName: Aggrecan core protein alternativeName: Cartilage-specific proteoglycan core protein shortName: CSPCP component recommendedName: Aggrecan core protein 2 /component |
| geneName | ACAN AGC1 |
| identifier | Q29011 |
| isSequenceChanged | FALSE |
| keyword | Calcium Direct protein sequencing Disulfide bond Extracellular matrix Glycoprotein Immunoglobulin domain Lectin Metal-binding Proteoglycan Reference proteome Repeat Secreted Signal Sushi |
| modified | [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ACAN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PGCA_PIG A0A287B863 O18833 Q7M2W7 |
| sequenceLength | 2434 |
| species | [Species:49633] Sus scrofa |
| (referenceEntity) | [EntityWithAccessionedSequence:3814807] ACAN C-terminal fragment [extracellular region] [Sus scrofa] [EntityWithAccessionedSequence:3814816] ACAN [extracellular region] [Sus scrofa] [EntityWithAccessionedSequence:3814819] ACAN N-terminal fragment [extracellular region] [Sus scrofa] |
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No pathways have been reviewed or authored by UniProt:Q29011 ACAN (3814808)
