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Details on Person EP300 [nucleoplasm]
Class:Id EntityWithAccessionedSequence:381325 _displayName EP300 [nucleoplasm] _timestamp 2013-06-10 12:54:56 compartment [Compartment:7660] nucleoplasm created [InstanceEdit:381302] May, B, 2008-11-19 19:18:44 endCoordinate 2414 modified [InstanceEdit:381391] May, B, 2008-11-19 19:19:43 [InstanceEdit:1368964] May, B, 2011-07-01 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:3662332] Jupe, S, 2013-06-07 [InstanceEdit:3697937] Jupe, S, 2013-06-10 name EP300 referenceEntity [ReferenceGeneProduct:61164] UniProt:Q09472 EP300 [Homo sapiens] species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1108765] R-HSA-381325.1 startCoordinate 2 (activeUnit) [PositiveGeneExpressionRegulation:2976565] Positive gene expression regulation by 'NOTCH2 coactivator complex:p-S133-CREB1:EP300:GZMB Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:3215147] Positive gene expression regulation by 'p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:4088166] Positive gene expression regulation by 'p-T611,S730,S739-FOXM1:EP300:CDC25A Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5634068] Positive gene expression regulation by 'atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:5634072] Positive gene expression regulation by 'atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:5634074] Positive gene expression regulation by 'atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:5634091] Positive gene expression regulation by 'atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:5634093] Positive gene expression regulation by 'atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:9613458] Positive gene expression regulation by 'ID1,ID3 genes:p-S133-CREB1:LYL1:EP300 [nucleoplasm]' [PositiveGeneExpressionRegulation:9620692] Positive gene expression regulation by 'VGF gene:p-CREB:p-ATFs:ASCL1:TCF12:EP300 [nucleoplasm]' (hasCandidate) [CandidateSet:9620507] KAT2B,(EP300) [nucleoplasm] [Homo sapiens] (hasComponent) [Complex:381367] PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] [Homo sapiens] [Complex:1234099] HIF:CBP:p300 [nucleoplasm] [Homo sapiens] [Complex:1234152] HIF-1A:CBP:p300 [nucleoplasm] [Homo sapiens] [Complex:1368124] RORA:Coactivator [nucleoplasm] [Homo sapiens] [Complex:1604462] NOTCH1 Coactivator Complex [nucleoplasm] [Homo sapiens] [Complex:2064911] xNOTCH1 Coactivator Complex [nucleoplasm] [Homo sapiens] [Complex:2065276] mNICD1 Chimeric Enhancer Complex [nucleoplasm] [Homo sapiens] [Complex:2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] [Homo sapiens] [Complex:2976561] NOTCH2 coactivator complex:p-S133-CREB1:EP300:GZMB Gene [nucleoplasm] [Homo sapiens] [Complex:3215149] p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm] [Homo sapiens] (hasMember) [DefinedSet:381297] Coactivators of PPARG Target Genes [nucleoplasm] [Homo sapiens] [DefinedSet:1027362] CREBBP,EP300 [nucleoplasm] [Homo sapiens] [DefinedSet:9023862] histone acetyltransferases [nucleoplasm] [Homo sapiens] (input) [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands [Homo sapiens] [BlackBoxEvent:1234167] Formation of HIF:CBP:p300 complex at promoters [Homo sapiens] [Reaction:1912394] NICD1 in complex with RBPJ (CSL) recruits MAML [Homo sapiens] [Reaction:2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML [Homo sapiens] [Reaction:2976563] NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter [Homo sapiens] [Reaction:3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter [Homo sapiens] [Reaction:3222093] BRD7 binds TP53 and EP300 [Homo sapiens] [FailedReaction:3701014] TP53 R175H does not bind GADD45A promoter [Homo sapiens] [Reaction:3899291] SUMOylation of EP300 with SUMO1 [Homo sapiens] [Reaction:4088162] FOXM1 binds CDC25A promoter [Homo sapiens] (output) [Reaction:1912391] NICD1 is phosphorylated by CDK8 [Homo sapiens] [Reaction:2065178] CDK8 phosphorylates xNICD1 [Homo sapiens] [Reaction:2220971] CDK8 phosphorylates NICD1 PEST domain mutants [Homo sapiens] [Reaction:8952058] CCND1 binds RUNX3 and displaces EP300 [Homo sapiens] [Reaction:9617735] TXN disrupts FOXO4 complex with EP300 [Homo sapiens] [Reaction:9617742] TXN disrupts Foxo4 comples with EP300 [Homo sapiens] [Reaction:9617757] EP300 acetylates Foxo4 [Homo sapiens] (physicalEntity) [CatalystActivity:3662301] histone acetyltransferase activity of EP300 [nucleoplasm] [CatalystActivity:9701519] protein-lysine-acetyltransferase activity of EP300 [nucleoplasm] [PhysicalEntityCellType:9979132] EP300 [nucleoplasm] in endothelial tip cell (regulator) [NegativeRegulation:8952420] Negative regulation by 'EP300 [nucleoplasm]' (updatedInstance) [_UpdateTracker:9882437] Update Tracker - [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] - v45:[addName] [_UpdateTracker:9887478] Update Tracker - [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] - v46:[modifyName, modifyStartCoordinate]
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Pathways
No pathways have been reviewed or authored by EP300 [nucleoplasm] (381325)
