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Details on Person EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK

Class:IdReaction:381111
_displayNameEIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
_doReleaseTRUE
_timestamp2019-02-02 08:52:59
authored[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
catalystActivity[CatalystActivity:381179] protein serine/threonine kinase activity of PERK dimer [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
edited[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
input[SimpleEntity:113592] ATP [cytosol]
[Complex:72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:381208] Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells
[LiteratureReference:535547] Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
[LiteratureReference:535531] Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha
[LiteratureReference:535585] Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases
[LiteratureReference:535497] Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
[LiteratureReference:381145] PERK in the life and death of the pancreatic beta-cell
modified[InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07
[InstanceEdit:387183] May, B, 2008-12-01 10:46:49
[InstanceEdit:387549] Gopinathrao, G, 2008-12-03 02:18:12
[InstanceEdit:420829] May, B, 2009-05-14 02:25:54
[InstanceEdit:422153] D'Eustachio, P, 2009-05-26 22:17:07
[InstanceEdit:422549] D'Eustachio, P, 2009-06-02 00:54:02
[InstanceEdit:425352] May, B, 2009-06-03
[InstanceEdit:425748] May, B, 2009-06-05
[InstanceEdit:535480] May, B, 2010-03-04
[InstanceEdit:638651] May, B, 2010-04-30
[InstanceEdit:9633028] May, Bruce, 2018-12-27
[InstanceEdit:9635379] May, Bruce, 2019-02-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameEIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
output[SimpleEntity:29370] ADP [cytosol]
[Complex:9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2009-06-24
reviewed[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
[InstanceEdit:638652] Urano, F, 2010-04-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105744] R-HSA-381111.3
summation[Summation:380990] The C-terminal domain of PERK (EIF2AK3) has kinase activity ...
(hasEvent)[Pathway:381042] PERK regulates gene expression [Homo sapiens]
(precedingEvent)[BlackBoxEvent:381128] Translation of ATF4 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777868] Update Tracker - [Reaction:381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - v68:[add_removeInput, add_removeOutput]
[_UpdateTracker:9787290] Update Tracker - [Reaction:381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - v46:[modifyText]
[_UpdateTracker:9790693] Update Tracker - [Reaction:381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - v33:[add_removeLiteratureReference]
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