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Details on Person Phosphorylated AMPK binds AMP

Class:IdReaction:380930
_displayNamePhosphorylated AMPK binds AMP
_doReleaseTRUE
_timestamp2024-07-31 17:48:59
authored[InstanceEdit:380973] Katajisto, P, Makela, T, Wu, J, 2008-11-19
catalystActivity[CatalystActivity:9917191] AMP binding activity of p-AMPK heterotrimer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
edited[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
input[Complex:380934] p-AMPK heterotrimer [cytosol] [Homo sapiens]
[SimpleEntity:76577] AMP [cytosol]
literatureReference[LiteratureReference:380939] 5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC
[LiteratureReference:380958] Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
modified[InstanceEdit:381843] Jassal, B, 2008-11-21 15:07:04
[InstanceEdit:388392] Jassal, B, 2008-12-03 10:49:29
[InstanceEdit:388851] Jassal, B, 2008-12-16 13:38:33
[InstanceEdit:447056] Jassal, B, 2009-11-20
[InstanceEdit:449022] Jassal, B, 2009-11-27
[InstanceEdit:449166] Matthews, L, 2009-11-30
[InstanceEdit:500332] Jassal, B, 2010-02-03
[InstanceEdit:5687546] Jupe, Steve, 2015-04-08
[InstanceEdit:5687631] Jupe, Steve, 2015-04-08
[InstanceEdit:5693184] Jupe, Steve, 2015-05-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9917193] D'Eustachio, Peter, 2024-07-31
namePhosphorylated AMPK binds AMP
output[Complex:380931] p-AMPK heterotrimer:AMP [cytosol] [Homo sapiens]
precedingEvent
releaseDate2010-03-16
reviewed[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105088] R-HSA-380930.3
summation[Summation:380978] If AMP:ATP ratio rises, AMP (instead of ATP) is bound by the...
(hasEvent)[Pathway:380972] Energy dependent regulation of mTOR by LKB1-AMPK [Homo sapiens]
(precedingEvent)[Reaction:163691] Phosphorylation of ChREBP at Serine 556 by AMPK [Homo sapiens]
[Reaction:200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis [Homo sapiens]
[Reaction:380927] p-AMPK phosphorylates TSC1:TSC2 [Homo sapiens]
[Reaction:447074] AMPK phosphorylates Raptor in the mTORC1 complex [Homo sapiens]
[Reaction:1592244] AMPK phosphorylates PPARGC1A [Homo sapiens]
[Reaction:5673768] p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex [Homo sapiens]
[Reaction:9859676] AMPK phosphorylates CRY1 on serine-71 and serine-280 [Homo sapiens]
[Reaction:9859709] AMPK phosphorylates CKIepsilon [Homo sapiens]
(updatedInstance)[_UpdateTracker:9919464] Update Tracker - [Reaction:380930] Phosphorylated AMPK binds AMP - v90:[removeCatalystActivity]
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