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Details on Person Assembly of the NuMA:Dynactin Dynein complex on microtubules

Class:Id	BlackBoxEvent:380511
_displayName	Assembly of the NuMA:Dynactin Dynein complex on microtubules
_timestamp	2017-03-17 15:11:18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:380514] Matthews, L, 2008-11-13 13:02:59
edited	[InstanceEdit:8982354] Orlic-Milacic, Marija, 2017-03-17
input	[Complex:380495] p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] [Homo sapiens] [Complex:2029120] Dynactin [cytosol] [Homo sapiens] [Complex:2029145] Dynein complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:8981855] NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function [LiteratureReference:380789] Epitope mapping and direct visualization of the parallel, in-register arrangement of the double-stranded coiled-coil in the NuMA protein [LiteratureReference:380795] Formation of spindle poles by dynein/dynactin-dependent transport of NuMA [LiteratureReference:380472] Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice [LiteratureReference:380791] Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin [LiteratureReference:380801] Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex [LiteratureReference:380796] Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued
modified	[InstanceEdit:380799] Matthews, L, 2008-11-14 14:41:48 [InstanceEdit:387111] Matthews, L, 2008-12-01 04:46:41 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8982290] Orlic-Milacic, Marija, 2017-03-16 [InstanceEdit:8982354] Orlic-Milacic, Marija, 2017-03-17 [InstanceEdit:8982355] Orlic-Milacic, Marija, 2017-03-17
name	Assembly of the NuMA:Dynactin Dynein complex on microtubules
output	[Complex:380509] p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules:Dynactin:Dynein [cytosol] [Homo sapiens]
precedingEvent	[Reaction:380316] Association of NuMA with microtubules [Homo sapiens] [Reaction:380508] Translocation of NuMA to the centrosomes [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8889116] R-HSA-380511.1
summation	[Summation:380794] Evidence suggests that dynactin associates with several NuMA...
(hasEvent)	[Pathway:380320] Recruitment of NuMA to mitotic centrosomes [Homo sapiens]
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No pathways have been reviewed or authored by Assembly of the NuMA:Dynactin Dynein complex on microtubules (380511)