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Details on Person Many unrelated GPCRs couple with the Gi G-protein subtype. T...
| Class:Id | Summation:380125 |
|---|---|
| _displayName | Many unrelated GPCRs couple with the Gi G-protein subtype. T... |
| _timestamp | 2010-05-19 16:50:00 |
| created | [InstanceEdit:380069] Jassal, Bijay, 2008-11-07 |
| literatureReference | [LiteratureReference:380099] The G protein subunit gene families |
| modified | [InstanceEdit:380136] Jassal, Bijay, 2008-11-07 [InstanceEdit:751025] Jupe, S, 2010-05-19 |
| text | Many unrelated GPCRs couple with the Gi G-protein subtype. The G-alpha (i) subunit inhibits the production of cAMP from ATP. In turn, this results in decreased activity of cAMP-dependent protein kinase. There are 8 types of G-alpha (i) known to date:G(i)1, G(i)2, G(i)3, G(i)o, G(i)z, G(i)gust (gustducin) and two G(i)t (retinal transducin) (Downes GB and Gautam N, 1999). Once GDP is exchanged for GTP on the alpha subunit, it dissociates from the G-beta-gamma subunit. |
| (summation) | [Reaction:749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi [Homo sapiens] [Reaction:9664331] C3a:C3AR1 binds inactive heterotrimeric G-protein Gi [Homo sapiens] |
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No pathways have been reviewed or authored by Many unrelated GPCRs couple with the Gi G-protein subtype. T... (380125)
