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Details on Person alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate

Class:Id	Reaction:379864
_displayName	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
_doRelease	TRUE
_timestamp	2009-03-19 09:48:51
authored	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
catalystActivity	[CatalystActivity:379647] alanine-tRNA ligase activity of AARS [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:379847] D'Eustachio, P, 2008-11-05 23:09:57
edited	[InstanceEdit:386989] D'Eustachio, P, 2008-11-29 15:41:00
input	[SimpleEntity:29432] L-Ala [cytosol] [GenomeEncodedEntity:379731] tRNA(Ala) [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:379883] Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition [LiteratureReference:389171] Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
modified	[InstanceEdit:379892] D'Eustachio, P, 2008-11-05 23:10:56 [InstanceEdit:383273] D'Eustachio, P, 2008-11-24 15:45:47 [InstanceEdit:386990] D'Eustachio, P, 2008-11-29 15:46:40 [InstanceEdit:387427] D'Eustachio, P, 2008-12-02 17:01:51 [InstanceEdit:389226] D'Eustachio, P, 2008-12-23 21:44:12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
output	[GenomeEncodedEntity:379700] Ala-tRNA(Ala) [cytosol] [Homo sapiens] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2008-12-17
reviewed	[InstanceEdit:387428] Antonellis, A, 2008-12-02 16:58:45
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:389225] D'Eustachio, P, 2008-12-23 21:40:28
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387672] R-HSA-379864.2
summation	[Summation:379855] AARS (cytosolic alanyl tRNA synthetase) catalyzes the reacti...
(hasEvent)	[Pathway:379716] Cytosolic tRNA aminoacylation [Homo sapiens]
(inferredFrom)	[Reaction:1113164] alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate [Oryza sativa]
(orthologousEvent)	[Reaction:1113164] alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate [Oryza sativa]
(updatedInstance)	[_UpdateTracker:9791650] Update Tracker - [Reaction:379864] alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate - v28:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (379864)