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Details on Person AARS (cytosolic alanyl tRNA synthetase) catalyzes the reacti...
| Class:Id | Summation:379855 |
|---|---|
| _displayName | AARS (cytosolic alanyl tRNA synthetase) catalyzes the reacti... |
| _timestamp | 2008-12-23 21:44:16 |
| created | [InstanceEdit:379847] D'Eustachio, P, 2008-11-05 23:09:57 |
| modified | [InstanceEdit:379892] D'Eustachio, P, 2008-11-05 23:10:56 [InstanceEdit:389226] D'Eustachio, P, 2008-12-23 21:44:12 |
| text | AARS (cytosolic alanyl tRNA synthetase) catalyzes the reaction of alanine, tRNA(ala), and ATP to form Ala tRNA(Ala), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a monomer (Shiba et al. 1995). A mutation in the editing domain of the mouse Aars gene results in misincorporation of non-cognate amino acids into cellular proteins. This is associated with protein misfolding in Purkinje cells and a phenotype consistent with human ataxia (Lee et al. 2006). |
| (summation) | [Reaction:379864] alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate [Homo sapiens] |
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No pathways have been reviewed or authored by AARS (cytosolic alanyl tRNA synthetase) catalyzes the reacti... (379855)
