Query author contributions in Reactome
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Details on Person The cAMP-responsive element binding protein (CREB), a key re...
| Class:Id | Summation:379800 |
|---|---|
| _displayName | The cAMP-responsive element binding protein (CREB), a key re... |
| _timestamp | 2018-09-21 14:34:56 |
| created | [InstanceEdit:379807] Jassal, B, 2008-11-05 15:52:07 |
| modified | [InstanceEdit:9615340] Orlic-Milacic, Marija, 2018-08-01 [InstanceEdit:9619198] Orlic-Milacic, Marija, 2018-09-14 [InstanceEdit:9620229] Orlic-Milacic, Marija, 2018-09-21 |
| text | The cAMP-responsive element binding protein (CREB), a key regulator of gene expression, is activated by phosphorylation on Ser-133. Several different protein kinases possess the capability of driving this phosphorylation, making it a point of convergence for multiple intracellular signaling cascades. Work in neurons has indicated that physiologic synaptic stimulation recruits a fast calmodulin kinase IV (CaMKIV)-dependent pathway that dominates early signaling to CREB. Activated CaMKIV (CAMK4) phosphorylates CREB1 at S133, thereby initiating the transcription of CREB1-regulated set of genes, leading to protein synthesis and long lasting changes that underlie synaptic plasticity. |
| (summation) | [Reaction:111912] CaMK4 phosphorylates CREB1 [Homo sapiens] |
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No pathways have been reviewed or authored by The cAMP-responsive element binding protein (CREB), a key re... (379800)
