Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Senescence-Associated Secretory Phenotype (SASP)

Class:IdPathwayDiagram:3797208
_displayNameDiagram of Senescence-Associated Secretory Phenotype (SASP)
_timestamp2021-08-03 18:25:47
created[InstanceEdit:3797207] Orlic-Milacic, M, 2013-07-05
height1272
modified[InstanceEdit:3827956] Orlic-Milacic, M, 2013-07-08
[InstanceEdit:3857344] Orlic-Milacic, M, 2013-07-09
[InstanceEdit:3857350] Orlic-Milacic, M, 2013-07-09
[InstanceEdit:3858388] Orlic-Milacic, M, 2013-07-09
[InstanceEdit:4568741] Orlic-Milacic, M, 2013-09-16
[InstanceEdit:4608701] Orlic-Milacic, M, 2013-09-23
[InstanceEdit:5147978] Orlic-Milacic, M, 2013-11-18
[InstanceEdit:6809183] Rothfels, Karen, 2015-11-09
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8932784] Orlic-Milacic, Marija, 2016-07-28
[InstanceEdit:8932866] Orlic-Milacic, Marija, 2016-07-29
[InstanceEdit:8932868] Orlic-Milacic, Marija, 2016-07-29
[InstanceEdit:8979074] Orlic-Milacic, Marija, 2017-02-21
[InstanceEdit:8979103] Orlic-Milacic, Marija, 2017-02-21
[InstanceEdit:8979221] Orlic-Milacic, Marija, 2017-02-22
[InstanceEdit:8979267] Orlic-Milacic, Marija, 2017-02-23
[InstanceEdit:9667207] Orlic-Milacic, Marija, 2019-11-08
[InstanceEdit:9749442] Orlic-Milacic, Marija, 2021-08-03
representedPathway[Pathway:2559582] Senescence-Associated Secretory Phenotype (SASP) [Homo sapiens]
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<displayName>INK4</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1132" reactomeId="182579" position="1104 390" bounds="1072 365 64 50" textPosition="1081 366" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDK4,CDK6:INK4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1198" reactomeId="3858376" position="317 336" bounds="278 311 79 51" textPosition="279 338"> <Properties> <displayName>CEBPB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1199" reactomeId="1112525" position="203 299" bounds="151 281 105 36" textPosition="152 282" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y705-STAT3 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1312" reactomeId="194047" position="826 449" bounds="794 426 64 47" textPosition="796 424" 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points="588 406, 587 379, 589 364" position="587 379" lineWidth="1.0"> <Inputs> <Input id="628" points="588 425" /> <Input id="633" points="631 406" /> </Inputs> <Outputs> <Output id="634" points="634 364" /> <Output id="635" points="588 347" /> </Outputs> <Catalysts> <Catalyst id="628" points="576 425, 566 404" /> </Catalysts> <Inhibitors> <Inhibitor id="629" points="417 439" /> </Inhibitors> <Properties> <displayName>CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="642" reactomeId="3788725" points="389 613, 389 613, 389 645" position="389 613" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="627" points="391 590" /> <Input id="643" points="434 614" /> </Inputs> <Outputs> <Output id="644" /> </Outputs> <Properties> <displayName>Cdh1:APC/C complex binds EHMT1:EHMT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="645" reactomeId="3788724" points="390 708, 391 726, 391 870" position="391 726" lineWidth="1.0"> <Inputs> <Input id="644" points="389 684" /> <Input id="646" stoichiometry="2" points="422 709" /> </Inputs> <Outputs> <Output id="647" /> </Outputs> <Catalysts> <Catalyst id="644" points="378 684, 362 708" /> </Catalysts> <Properties> <displayName>Cdh1:APC/C ubiquitinates EHMT1 and EHMT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="648" reactomeId="3788748" points="732 641, 714 642, 687 639" position="714 642" lineWidth="1.0"> <Inputs> <Input id="649" stoichiometry="4" points="754 693" /> <Input id="650" points="748 636" /> </Inputs> <Outputs> <Output id="651" stoichiometry="4" points="657 686" /> <Output id="652" points="649 638" /> </Outputs> <Catalysts> <Catalyst id="643" points="514 602, 551 591, 661 591" /> </Catalysts> <Properties> <displayName>EHMT1:EHMT2 methylates IL6 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="659" reactomeId="3788745" points="738 770, 718 769, 686 769" position="718 769" lineWidth="1.0"> <Inputs> <Input id="649" stoichiometry="4" points="755 723" /> <Input id="660" points="768 761" /> </Inputs> <Outputs> <Output id="661" points="648 768" /> <Output id="651" stoichiometry="4" points="656 722" /> </Outputs> <Catalysts> <Catalyst id="643" points="488 630, 550 818, 659 819" /> </Catalysts> <Properties> <displayName>EHMT1:EHMT2 methylates IL8 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="662" reactomeId="3790130" points="935 605, 1003 644, 1193 644" position="1003 644" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1392" /> </Inputs> <Outputs> <Output id="663" /> </Outputs> <Inhibitors> <Inhibitor id="643" points="501 602, 535 583, 946 582" /> <Inhibitor id="1398" points="985 656" /> </Inhibitors> <Activators> <Activator id="1010" points="972 475" /> <Activator id="627" points="448 567, 965 552" /> </Activators> <Properties> <displayName>Regulation of IL6 transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="664" reactomeId="3790137" points="889 823, 961 839, 1190 843" position="961 839" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1367" /> </Inputs> <Outputs> <Output id="665" /> </Outputs> <Inhibitors> <Inhibitor id="643" points="487 630, 539 901, 947 905" /> </Inhibitors> <Activators> <Activator id="1042" points="959 786" /> <Activator id="627" points="339 567, 301 567, 296 920, 992 920" /> </Activators> <Properties> <displayName>Stimulation of IL8 transcription in senescent cells</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="667" reactomeId="3797196" points="720 1068, 720 1066, 781 1043" position="720 1066" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="668" points="681 1078" /> <Input id="669" points="700 1044" /> </Inputs> <Outputs> <Output id="670" /> </Outputs> <Properties> <displayName>AP-1 transcription factor binds IGFBP7 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="677" interactionType="Activate" points="594 1024, 624 1023" position="609 1023" lineWidth="2.0"> <Inputs> <Input id="666" /> </Inputs> <Outputs> <Output id="669" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="690" reactomeId="3797202" points="681 1078, 838 1092, 1202 1096" position="838 1092" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="668" /> </Inputs> <Outputs> <Output id="691" /> </Outputs> <Activators> <Activator id="670" points="837 1054" /> </Activators> <Properties> <displayName>AP-1 stimulates transcription of IGFBP7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="701" reactomeId="198746" points="514 136, 539 135, 562 135" position="539 135" lineWidth="1.0"> <Inputs> <Input id="702" points="492 136" /> <Input id="703" stoichiometry="6" points="502 161" /> </Inputs> <Outputs> <Output id="704" points="605 134" /> <Output id="705" stoichiometry="6" points="576 165" /> </Outputs> <Catalysts> <Catalyst id="706" points="539 104" /> </Catalysts> <Properties> <displayName>ERK1/2/5 activate RSK1/2/3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="902" reactomeId="3857329" points="416 222, 437 222, 464 222" position="437 222" lineWidth="1.0"> <Inputs> <Input id="904" points="408 238" /> <Input id="903" points="396 222" /> </Inputs> <Outputs> <Output id="905" points="498 220" /> <Output id="906" points="473 240" /> </Outputs> <Catalysts> <Catalyst id="907" points="310 162, 435 182" /> </Catalysts> <Properties> <displayName>MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="908" points="260 136, 353 90, 429 87" position="353 90" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="907" /> </Inputs> <Outputs> <Output id="706" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="951" reactomeId="3857328" points="646 219, 675 218, 700 219" position="675 218" lineWidth="1.0"> <Inputs> <Input id="905" points="612 219" /> <Input id="952" points="636 232" /> </Inputs> <Outputs> <Output id="953" points="732 217" /> <Output id="954" points="709 238" /> </Outputs> <Catalysts> <Catalyst id="704" points="675 165" /> </Catalysts> <Properties> <displayName>RPS6KA1/2/3 phosphorylates CEBPB on S321</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="970" interactionType="Activate" points="241 170, 241 214" position="241 192" lineWidth="2.0"> <Inputs> <Input id="907" /> </Inputs> <Outputs> <Output id="967" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="989" reactomeId="3857336" points="784 240, 783 279, 774 311" position="783 279" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="953" stoichiometry="2" /> </Inputs> <Outputs> <Output id="990" /> </Outputs> <Properties> <displayName>CEBPB homodimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1009" reactomeId="3857305" points="838 381, 878 419, 915 430" position="878 419" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1312" points="830 423" /> <Input id="990" points="794 353" /> <Input id="1392" points="935 605, 884 463" /> </Inputs> <Outputs> <Output id="1010" /> </Outputs> <Properties> <displayName>Activated CEBPB and NFKB complex bind IL6 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1041" reactomeId="3857308" points="855 682, 896 696, 933 730" position="896 696" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1312" points="828 476" /> <Input id="990" points="771 353, 780 461" /> <Input id="1367" points="889 823" /> </Inputs> <Outputs> <Output id="1042" /> </Outputs> <Properties> <displayName>Activated CEBPB and NFKB complex bind IL8 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1093" reactomeId="3857345" points="953 306, 954 306, 962 338" position="954 306" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="990" points="835 323" /> <Input id="1094" points="939 242" /> </Inputs> <Outputs> <Output id="1095" /> </Outputs> <Properties> <displayName>Activated CEBPB binds CDKN2B promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1120" reactomeId="3857348" points="939 242, 968 225, 1065 224" position="968 225" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1094" /> </Inputs> <Outputs> <Output id="1121" /> </Outputs> <Activators> <Activator id="1095" points="968 338" /> </Activators> <Properties> <displayName>Activated CEBPB stimulates transcription of CDKN2B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1128" reactomeId="182594" points="1128 323, 1128 322, 1112 362" position="1128 322" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1129" points="1109 320" /> <Input id="1130" points="1102 289" /> </Inputs> <Outputs> <Output id="1132" /> </Outputs> <Properties> <displayName>Association of INK4 family proteins with CDK4/6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1131" points="1096 238, 1096 255" position="1096 246" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1121" /> </Inputs> <Outputs> <Output id="1130" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1197" reactomeId="3858387" points="366 313, 366 272, 367 236" position="366 272" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1198" /> </Inputs> <Outputs> <Output id="903" /> </Outputs> <Activators> <Activator id="1199" points="259 290" /> </Activators> <Properties> <displayName>Activated STAT3 positively regulates CEBPB transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1331" reactomeId="4568737" points="730 960, 730 960, 766 963" position="730 960" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1332" points="681 939" /> <Input id="669" points="700 1002" /> </Inputs> <Outputs> <Output id="1333" /> </Outputs> <Properties> <displayName>AP-1 transcription factor binds IL1A promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1340" reactomeId="4568740" points="681 939, 1004 945, 1178 955" position="1004 945" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1332" /> </Inputs> <Outputs> <Output id="1341" /> </Outputs> <Activators> <Activator id="1333" points="930 974, 998 977" /> </Activators> <Properties> <displayName>AP-1 stimulates IL1A transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1349" interactionType="Activate" points="1261 933, 1334 889, 1333 528, 1184 528" position="1333 708" lineWidth="2.0"> <Inputs> <Input id="1341" /> </Inputs> <Outputs> <Output id="1348" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1350" interactionType="Activate" points="1010 529, 903 529, 848 476" position="903 529" lineWidth="2.0"> <Inputs> <Input id="1348" /> </Inputs> <Outputs> <Output id="1312" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1394" interactionType="Activate" points="241 76, 241 136" position="241 106" lineWidth="2.0" lineColor="255 51 51"> <Inputs> <Input id="1393" /> </Inputs> <Outputs> <Output id="907" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1396" interactionType="Activate" points="1231 659, 1280 705, 1274 1236, 583 1236" position="1277 970" lineWidth="2.0"> <Inputs> <Input id="663" /> </Inputs> <Outputs> <Output id="1395" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1397" interactionType="Activate" points="414 1237, 69 1242, 70 299, 148 299" position="69 770" lineWidth="2.0"> <Inputs> <Input id="1395" /> </Inputs> <Outputs> <Output id="1199" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1423" interactionType="Activate" points="1031 702, 992 684" position="1011 693" lineWidth="2.0"> <Inputs> <Input id="1422" /> </Inputs> <Outputs> <Output id="1398" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1428" interactionType="Activate" points="213 550, 289 534" position="251 542" lineWidth="2.0"> <Inputs> <Input id="1427" /> </Inputs> <Outputs> <Output id="626" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Senescence-Associated Secretory Phenotype (SASP) (3797208)
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