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Details on Person SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane

Class:Id	Reaction:379415
_displayName	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
_doRelease	TRUE
_timestamp	2025-08-14 07:46:46
authored	[InstanceEdit:386986] D'Eustachio, P, 2008-11-29 15:37:01
catalystActivity	[CatalystActivity:379423] amino acid transmembrane transporter activity of SLC7A7:SLC3A2 heterodimer [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:379411] D'Eustachio, P, 2008-10-28 22:22:39
crossReference	[DatabaseIdentifier:9960121] RHEA:70832
edited	[InstanceEdit:386986] D'Eustachio, P, 2008-11-29 15:37:01
input	[SimpleEntity:29468] L-Arg [cytosol] [SimpleEntity:351964] L-Leu [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
literatureReference	[LiteratureReference:379414] Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family
modified	[InstanceEdit:379437] D'Eustachio, P, 2008-10-28 22:22:56 [InstanceEdit:379694] D'Eustachio, P, 2008-11-04 21:55:05 [InstanceEdit:383274] D'Eustachio, P, 2008-11-24 15:53:47 [InstanceEdit:383344] Jassal, Bijay, 2008-11-26 [InstanceEdit:386987] D'Eustachio, P, 2008-11-29 15:39:34 [InstanceEdit:5660943] Jassal, Bijay, 2015-01-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9960120] Stephan, Ralf, 2025-07-07 [InstanceEdit:9963335] Stephan, Ralf, 2025-08-14 [InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
name	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine
negativePrecedingEvent	[NegativePrecedingEvent:9963354] Futile Cycle: SLC38A4 (ATA3)-mediated uptake of arginine and lysine [NegativePrecedingEvent:9963355] Futile Cycle: SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963416] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963413] Futile Cycle: SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963385] Futile Cycle: SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963390] Futile Cycle: SLC7A3 (CAT-3)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963408] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
output	[SimpleEntity:351977] L-Arg [extracellular region] [SimpleEntity:29588] L-Leu [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2008-12-17
reviewed	[InstanceEdit:383343] Jassal, Bijay, 2008-11-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387705] R-HSA-379415.3
summation	[Summation:379410] SLC7A7 as a heterodimer with SLC3A2 in the plasma membrane m...
(hasEvent)	[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
(normalReaction)	[FailedReaction:5660910] Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963375] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963379] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963400] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963404] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963414] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963420] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [NegativePrecedingEvent:9963425] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
(updatedInstance)	[_UpdateTracker:9785012] Update Tracker - [Reaction:379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - v52:[modifyText]
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