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Details on Person Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Class:Id	Reaction:379048
_displayName	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
_doRelease	TRUE
_timestamp	2017-07-11 09:39:40
authored	[InstanceEdit:380069] Jassal, Bijay, 2008-11-07
catalystActivity	[CatalystActivity:380089] guanyl-nucleotide exchange factor activity of LTC4:CyslTR1,2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:379045] Jassal, Bijay, 2008-10-10
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[Complex:749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:750995] The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins [LiteratureReference:383358] Stable association between G alpha(q) and phospholipase C beta 1 in living cells [LiteratureReference:383349] Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC) [LiteratureReference:383352] G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells [LiteratureReference:383347] Human G(alpha q): cDNA and tissue distribution
modified	[InstanceEdit:380069] Jassal, Bijay, 2008-11-07 [InstanceEdit:380570] Jassal, Bijay, 2008-11-13 [InstanceEdit:383357] Jassal, Bijay, 2008-11-26 [InstanceEdit:387044] D'Eustachio, P, 2008-11-29 18:34:39 [InstanceEdit:389875] Jassal, Bijay, 2009-01-19 [InstanceEdit:391180] Jassal, Bijay, 2009-02-13 [InstanceEdit:391824] Jassal, Bijay, 2009-02-24 [InstanceEdit:392260] Jassal, Bijay, 2009-03-02 [InstanceEdit:420459] Jassal, Bijay, 2009-05-12 [InstanceEdit:420735] Jassal, Bijay, 2009-05-13 [InstanceEdit:532506] Jupe, S, 2010-03-01 [InstanceEdit:749449] Jupe, S, 2010-05-18 [InstanceEdit:751025] Jupe, S, 2010-05-19 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8983501] Varusai, Thawfeek, 2017-03-24 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
output	[Complex:749447] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq [Homo sapiens] [Reaction:374173] AGT(25-32) binds to AGTR1 [Homo sapiens] [Reaction:9615348] AGT(25-32) binds to AGTR2 [Homo sapiens] [Reaction:375384] Bombesin-like receptors bind bombesin homologues [Homo sapiens] [Reaction:374331] Bradykinin receptors B1 and B2 bind to bradykinin [Homo sapiens] [Reaction:390649] CHRM1,3,5 bind acetylcholine [Homo sapiens] [Reaction:390930] 5-HT2 receptor can bind serotonin [Homo sapiens] [Reaction:390641] ADRA1A,B,D bind ADR,NAd [Homo sapiens] [Reaction:390912] HRH1 binds hist [Homo sapiens] [Reaction:391372] GNRHR binds GNRH1,2 [Homo sapiens] [Reaction:388468] AVP(20-28) binds AVPR1A,B [Homo sapiens] [Reaction:417908] P2RY1 binds ADP [Homo sapiens] [Reaction:417927] P2Y2 receptor binds ATP and UTP [Homo sapiens] [Reaction:417890] P2Y5 receptor can bind to LPA [Homo sapiens] [Reaction:417896] P2Y6 receptor can bind to UDP [Homo sapiens] [Reaction:417842] P2Y10 receptor can bind to LPA [Homo sapiens] [Reaction:417820] P2Y9 receptor can bind to LPA [Homo sapiens] [Reaction:163625] Glucagon binds to Glucagon receptor [Homo sapiens] [Reaction:419861] Melanospin is stimulated by light [Homo sapiens] [Reaction:420724] CASR binds Ca2+ [Homo sapiens] [Reaction:444208] MLNR (GPR38) is a receptor for motilin [Homo sapiens] [Reaction:444498] Thyrotropin-releasing hormone receptor binds thyrotropin [Homo sapiens] [Reaction:444620] Neuropeptide S receptor binds neuropeptide S [Homo sapiens] [Reaction:444691] Prokineticin receptors bind prokineticin [Homo sapiens] [Reaction:444202] Receptor FFAR1 binds free fatty acids [Homo sapiens] [Reaction:444171] Receptor FFAR2 binds carboxylates [Homo sapiens] [Reaction:444047] Receptor FFAR3 binds carboxylates [Homo sapiens] [Reaction:445113] Urotensin-2 receptor binds urotensin-2 and 2B [Homo sapiens] [Reaction:444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors [Homo sapiens] [Reaction:947647] GHSR is a receptor for ghrelin [Homo sapiens] [Reaction:981832] NMUR2 binds neuromedin-S [Homo sapiens] [Reaction:964800] Neuromedin-U receptors bind neuromedins U, S [Homo sapiens] [Reaction:870269] Gastrin binds to CCK-B receptor [Homo sapiens] [Reaction:373075] Metabotropic glutamate receptors bind glutamate [Homo sapiens] [Reaction:444191] GPR120 is a receptor for unsaturated long-chain free fatty acids [Homo sapiens] [Reaction:444572] Zinc is an agonist of GPR39 [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:387043] D'Eustachio, P, 2008-11-29 18:33:05
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387554] R-HSA-379048.3
summation	[Summation:380079] G alpha q protein (or Gq/11) consists of four family members...
(hasEvent)	[Pathway:416476] G alpha (q) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:749452] The Ligand:GPCR:Gq complex dissociates [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790686] Update Tracker - [Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - v33:[addLiteratureReference, add_removeInput, add_removeOutput] [_UpdateTracker:9791628] Update Tracker - [Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - v28:[add_removeOutput]
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