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Details on Person Liganded Gs-activating GPCR acts as a GEF for Gs

Class:Id	Reaction:379044
_displayName	Liganded Gs-activating GPCR acts as a GEF for Gs
_doRelease	TRUE
_timestamp	2017-07-11 09:39:48
authored	[InstanceEdit:391180] Jassal, Bijay, 2009-02-13
catalystActivity	[CatalystActivity:391182] guanyl-nucleotide exchange factor activity of Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:379045] Jassal, Bijay, 2008-10-10
edited	[InstanceEdit:391180] Jassal, Bijay, 2009-02-13
input	[Complex:744885] Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:391183] Isolation and characterization of the human Gs alpha gene [LiteratureReference:390777] Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants [LiteratureReference:390897] Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells [LiteratureReference:391036] Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein [LiteratureReference:391019] Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor
modified	[InstanceEdit:380069] Jassal, Bijay, 2008-11-07 [InstanceEdit:380565] Jassal, Bijay, 2008-11-13 [InstanceEdit:391180] Jassal, Bijay, 2009-02-13 [InstanceEdit:391185] Jassal, Bijay, 2009-02-13 [InstanceEdit:391824] Jassal, Bijay, 2009-02-24 [InstanceEdit:392160] Jassal, Bijay, 2009-02-27 [InstanceEdit:392260] Jassal, Bijay, 2009-03-02 [InstanceEdit:398118] Matthews, L, 2009-03-17 05:35:58 [InstanceEdit:420077] Jassal, Bijay, 2009-05-11 [InstanceEdit:420459] Jassal, Bijay, 2009-05-12 [InstanceEdit:420875] Jassal, Bijay, 2009-05-14 [InstanceEdit:532506] Jupe, S, 2010-03-01 [InstanceEdit:744888] Jupe, S, 2010-05-18 [InstanceEdit:745612] Jupe, S, 2010-05-18 [InstanceEdit:749449] Jupe, S, 2010-05-18 [InstanceEdit:751025] Jupe, S, 2010-05-19 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8982644] Varusai, Thawfeek, 2017-03-21 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded Gs-activating GPCR acts as a GEF for Gs
output	[Complex:744890] GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:744887] Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs [Homo sapiens] [Reaction:390674] ADRB1 bind ADR,NAd [Homo sapiens] [Reaction:390835] DRD1,5 bind DA [Homo sapiens] [Reaction:390909] HRH2 binds hist [Homo sapiens] [Reaction:390931] 5-HT4, 6 and 7 receptors can bind serotonin [Homo sapiens] [Reaction:391211] Trace amine-associated receptors can bind trace amines [Homo sapiens] [Reaction:391378] Follicle-stimulating hormone receptor can bind FSH [Homo sapiens] [Reaction:391377] Luteinizing hormone receptor can bind LH [Homo sapiens] [Reaction:391942] IP receptor can bind prostacyclin [Homo sapiens] [Reaction:391375] TSHR binds TSH/Thyrostimulin [Homo sapiens] [Reaction:418925] ADORA2A,B bind Ade-Rib [Homo sapiens] [Reaction:392263] AVP(20-28) binds AVPR2 [Homo sapiens] [Reaction:420265] AMY1-3 bind IAPP(34-70) [Homo sapiens] [Reaction:419843] CALCA(83-119) binds CALCR [Homo sapiens] [Reaction:420127] CGRP receptor can bind calcitonin gene-related peptides [Homo sapiens] [Reaction:420173] CRHR1,CRHR2-1 binds CRH,UCN [Homo sapiens] [Reaction:420214] The adrenomedullin receptor can bind adrenomedullin and intermedin [Homo sapiens] [Reaction:420274] GIP receptor binds gastric inhibitory peptide [Homo sapiens] [Reaction:163625] Glucagon binds to Glucagon receptor [Homo sapiens] [Reaction:420123] Glucagon-like receptor 2 binds GLP2 [Homo sapiens] [Reaction:381612] GLP1R binds GLP1 [Homo sapiens] [Reaction:420243] GHRH receptor binds GHRH [Homo sapiens] [Reaction:420131] The PACAP receptor binds PACAP [Homo sapiens] [Reaction:420233] VIP receptors bind VIP [Homo sapiens] [Reaction:420489] Parathyroid hormone receptor can bind parathyroid hormone [Homo sapiens] [Reaction:420202] Secretin receptor binds secretin [Homo sapiens] [Reaction:444620] Neuropeptide S receptor binds neuropeptide S [Homo sapiens] [Reaction:444838] Relaxin receptor 1 binds relaxin 2 and 3 [Homo sapiens] [Reaction:444879] Relaxin receptor 2 binds relaxin 2 and INSL3 [Homo sapiens] [Reaction:444654] G-protein coupled bile acid receptor binds lithocholic acid [Homo sapiens] [Reaction:444572] Zinc is an agonist of GPR39 [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:392262] D'Eustachio, P, 2009-03-02 09:24:35
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398437] R-HSA-379044.3
summation	[Summation:751022] The liganded receptor undergoes a conformational change, gen...
(hasEvent)	[Pathway:418555] G alpha (s) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:744886] The Ligand:GPCR:Gs complex dissociates [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781881] Update Tracker - [Reaction:379044] Liganded Gs-activating GPCR acts as a GEF for Gs - v60:[modifyText] [_UpdateTracker:9790537] Update Tracker - [Reaction:379044] Liganded Gs-activating GPCR acts as a GEF for Gs - v33:[add_removeInput, add_removeOutput, add_removeSummation] [_UpdateTracker:9939643] Update Tracker - [Reaction:379044] Liganded Gs-activating GPCR acts as a GEF for Gs - v92:[modifyText]
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