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Details on Person SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate

Class:Id	Reaction:378513
_displayName	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate
_doRelease	TRUE
_timestamp	2025-08-13 18:23:22
authored	[InstanceEdit:386986] D'Eustachio, P, 2008-11-29 15:37:01
catalystActivity	[CatalystActivity:378514] amino acid transmembrane transporter activity of SLC7A11:SLC3A2 heterodimer [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:378518] D'Eustachio, P, 2008-09-22 18:03:59
crossReference	[DatabaseIdentifier:9960117] RHEA:70996
edited	[InstanceEdit:386986] D'Eustachio, P, 2008-11-29 15:37:01
input	[SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:379429] CySS- [extracellular region]
literatureReference	[LiteratureReference:378516] Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc- [LiteratureReference:378520] Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility
modified	[InstanceEdit:379694] D'Eustachio, P, 2008-11-04 21:55:05 [InstanceEdit:383274] D'Eustachio, P, 2008-11-24 15:53:47 [InstanceEdit:383344] Jassal, Bijay, 2008-11-26 [InstanceEdit:386987] D'Eustachio, P, 2008-11-29 15:39:34 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9960120] Stephan, Ralf, 2025-07-07 [InstanceEdit:9963146] Stephan, Ralf, 2025-08-13 [InstanceEdit:9963210] Stephan, Ralf, 2025-08-13
name	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate
negativePrecedingEvent	[NegativePrecedingEvent:9963229] Abundant Molecules: SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
output	[SimpleEntity:210382] L-Glu [extracellular region] [SimpleEntity:379444] CySS- [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2008-12-17
reviewed	[InstanceEdit:383343] Jassal, Bijay, 2008-11-26 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387587] R-HSA-378513.3
structureModified	[InstanceEdit:9960120] Stephan, Ralf, 2025-07-07
summation	[Summation:378509] SLC7A11 as a heterodimer with SLC3A2 in the plasma membrane ...
(hasEvent)	[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963409] Futile Cycle: SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate
(updatedInstance)	[_UpdateTracker:9964604] Update Tracker - [Reaction:378513] SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate - v94:[add_removeInput, add_removeOutput, modifyText]
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