Query author contributions in Reactome
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Details on Person Once associated with the endoplasmic reticulum membrane, PLA...
| Class:Id | Summation:378471 |
|---|---|
| _displayName | Once associated with the endoplasmic reticulum membrane, PLA... |
| _timestamp | 2024-07-31 13:54:34 |
| created | [InstanceEdit:378481] Jassal, B, 2008-09-18 10:23:12 |
| modified | [InstanceEdit:378499] Jassal, B, 2008-09-18 10:24:19 [InstanceEdit:2308252] D'Eustachio, P, 2012-06-05 [InstanceEdit:9915527] D'Eustachio, Peter, 2024-07-10 [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31 |
| text | Once associated with the endoplasmic reticulum membrane, PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine to produce arachidonate (AA), a precursor to inflammatory mediators. While several phospholipases can catalyze this reaction in cells overexpressing the enzymes, PLA2G4A is the major enzyme that catalyzes it in vivo (Reed et al. 2011). At the same time, possible physiological roles have been described for soluble phospholipases (sPLA) in the mobilization of arachidonate in some cell types or under some physiological conditions (Murakami et al. 2011). |
| (summation) | [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens] |
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No pathways have been reviewed or authored by Once associated with the endoplasmic reticulum membrane, PLA... (378471)
