Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1
Class:Id Reaction:3782535 _displayName TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 _doRelease TRUE _timestamp 2018-08-08 19:33:26 authored [InstanceEdit:3782612] May, B, 2013-06-30 catalystActivity [CatalystActivity:4090335] SUMO transferase activity of TRIM28 [nucleoplasm] catalystActivityReference [CatalystActivityReference:9643106] SUMO transferase activity of TRIM28 [nucleoplasm] Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain compartment [Compartment:7660] nucleoplasm created [InstanceEdit:3782606] May, B, 2013-06-30 edited [InstanceEdit:3782612] May, B, 2013-06-30 input [Complex:3782565] TRIM28:ZNF350 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:3782593] Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells [LiteratureReference:3782594] Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression [LiteratureReference:1220630] PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing [LiteratureReference:1220623] Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing [LiteratureReference:4090300] Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain [LiteratureReference:5626900] Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli modified [InstanceEdit:4090429] May, B, 2013-08-13 [InstanceEdit:5626908] May, Bruce, 2014-10-13 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9608079] May, Bruce, 2018-05-09 [InstanceEdit:9615866] May, Bruce, 2018-08-08 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 output [Complex:3782577] monoSUMO1-TRIM28:ZNF350 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] precedingEvent
releaseDate 2018-06-12 reviewed [InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:8880797] R-HSA-3782535.4 summation [Summation:3782564] The PHD domain of TRIM28 (KAP1) acts as a SUMO E3 ligase to ... (hasEvent) [Pathway:3899300] SUMOylation of transcription cofactors [Homo sapiens]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (3782535)
