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Details on Person PPP1R3C binds to glycogen:GYG2:GYS2

Class:Id	Reaction:3780997
_displayName	PPP1R3C binds to glycogen:GYG2:GYS2
_doRelease	TRUE
_timestamp	2024-12-11 21:03:51
authored	[InstanceEdit:3907318] D'Eustachio, P, 2013-07-19
catalystActivity	[CatalystActivity:9931455] protein-macromolecule adaptor activity of PPP1R3C [cytosol]
catalystActivityReference	[CatalystActivityReference:9931447] protein-macromolecule adaptor activity of PPP1R3C [cytosol] Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3781010] D'Eustachio, P, 2013-06-27
input	[EntityWithAccessionedSequence:3777102] PPP1R3C [cytosol] [Homo sapiens] [Complex:3322011] glycogen-GYG2:GYS2-a tetramer [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9931477] D'Eustachio, Peter, 2024-12-11
isChimeric	FALSE
literatureReference	[LiteratureReference:3777107] Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)
modified	[InstanceEdit:3781026] D'Eustachio, P, 2013-06-27 [InstanceEdit:3782665] D'Eustachio, P, 2013-07-01 [InstanceEdit:3907319] D'Eustachio, P, 2013-07-19 [InstanceEdit:4006080] D'Eustachio, P, 2013-07-26 [InstanceEdit:5333094] D'Eustachio, Peter, 2014-02-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11 [InstanceEdit:9931476] D'Eustachio, Peter, 2024-12-11
name	PPP1R3C binds to glycogen:GYG2:GYS2
output	[Complex:3777104] PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:3322016] GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a [Homo sapiens] [Reaction:3322009] GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 [Homo sapiens] [BlackBoxEvent:3780995] NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 [Homo sapiens] [Reaction:3781011] EPM2A dimer dephosphorylates phosphoglycogen-GYG2 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-09-18
reviewed	[InstanceEdit:5333091] Pederson, Bart, 2014-02-18 [InstanceEdit:4006079] Jassal, B, 2013-07-26
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545339] R-HSA-3780997.4
structureModified	[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
summation	[Summation:3781016] Protein phosphatase 1 regulatory subunit 3C (PPP1R3C, PTG) b...
(hasEvent)	[Pathway:3322077] Glycogen synthesis [Homo sapiens]
(precedingEvent)	[Reaction:3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786748] Update Tracker - [Reaction:3780997] PPP1R3C binds to glycogen:GYG2:GYS2 - v48:[modifyText] [_UpdateTracker:9939765] Update Tracker - [Reaction:3780997] PPP1R3C binds to glycogen:GYG2:GYS2 - v92:[removeCatalystActivity]
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