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Details on Person Dephosphorylation of inactive SRC by PTPB1

Class:Id	Reaction:377643
_displayName	Dephosphorylation of inactive SRC by PTPB1
_doRelease	TRUE
_timestamp	2011-02-13 16:01:14
authored	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
catalystActivity	[CatalystActivity:210705] protein tyrosine phosphatase activity of PTPN1 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:377642] Garapati, P V, 2008-09-15 18:46:55
edited	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
input	[Complex:377616] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:1215941] PTP-1B is an essential positive regulator of platelet integrin signaling [LiteratureReference:377572] Integrins and Src: dynamic duo of adhesion signaling
modified	[InstanceEdit:377697] Garapati, P V, 2008-09-16 06:32:25 [InstanceEdit:383276] Garapati, P V, 2008-11-24 15:56:28 [InstanceEdit:427420] D'Eustachio, P, 2009-06-19 [InstanceEdit:939908] Jupe, S, 2010-09-02 [InstanceEdit:939915] Jupe, S, 2010-09-02 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1215939] Garapati, P V, 2011-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dephosphorylation of inactive SRC by PTPB1
output	[Complex:377620] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:377644] Release of CSK from SRC [Homo sapiens] [Reaction:377641] Clustering of Integrin alphaIIb beta3 complexes [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:377695] Shattil, SJ, 2008-09-16 06:21:39
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387727] R-HSA-377643.2
summation	[Summation:377576] The integrin alphaIIb beta3:Inactive SRC complex recruits PT...
(hasEvent)	[Pathway:354192] Integrin signaling [Homo sapiens]
(precedingEvent)	[Reaction:377640] Autophosphorylation of SRC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790008] Update Tracker - [Reaction:377643] Dephosphorylation of inactive SRC by PTPB1 - v36:[addLiteratureReference, add_removeOutput] [_UpdateTracker:9790284] Update Tracker - [Reaction:377643] Dephosphorylation of inactive SRC by PTPB1 - v34:[modifyText] [_UpdateTracker:9791456] Update Tracker - [Reaction:377643] Dephosphorylation of inactive SRC by PTPB1 - v30:[add_removeOutput]
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