Query author contributions in Reactome
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Details on Person The integrin alphaIIb beta3:Inactive SRC complex recruits PT...
| Class:Id | Summation:377576 |
|---|---|
| _displayName | The integrin alphaIIb beta3:Inactive SRC complex recruits PT... |
| _timestamp | 2010-09-02 12:15:05 |
| created | [InstanceEdit:377575] Garapati, P V, 2008-09-15 17:55:00 |
| literatureReference | [LiteratureReference:377572] Integrins and Src: dynamic duo of adhesion signaling [LiteratureReference:939911] Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide |
| modified | [InstanceEdit:939908] Jupe, S, 2010-09-02 |
| text | The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. The phosphorylated tail of SRC tail interacts with the SH2 domain thereby repressing kinase activity; removal of phosphorylation activates SRC kinase activity. |
| (summation) | [Reaction:377643] Dephosphorylation of inactive SRC by PTPB1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The integrin alphaIIb beta3:Inactive SRC complex recruits PT... (377576)
