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Details on Person RHEB:GTP complex is hydrolysed by GIG:TSC1 complex

Class:IdReaction:377353
_displayNameRHEB:GTP complex is hydrolysed by GIG:TSC1 complex
_doReleaseFALSE
_timestamp2017-06-27 17:37:59
authored[InstanceEdit:386955] Williams, MG, 2008-09-08 16:49:12
catalystActivity[CatalystActivity:377206] GTPase activator activity of GIG [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:377173] Williams, MG, 2008-09-12 10:01:25
figure[Figure:376926] /figures/ADrosINRA48.jpg
input[Complex:377285] RHEB:GTP:GIG:TSC1 [plasma membrane] [Drosophila melanogaster]
literatureReference[LiteratureReference:377414] Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
[LiteratureReference:377025] Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
[LiteratureReference:377385] The GTPase-activating protein Rap1GAP uses a catalytic asparagine
[LiteratureReference:377217] Structural basis for the unique biological function of small GTPase RHEB
modified[InstanceEdit:386962] Williams, MG, 2008-11-27 15:15:51
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
nameRHEB:GTP complex is hydrolysed by GIG:TSC1 complex
output[Complex:377321] RHEB:GDP:GIG:TSC1 [plasma membrane] [Drosophila melanogaster]
[SimpleEntity:29372] Pi [cytosol]
precedingEvent
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8922915] R-DME-377353.1
summation[Summation:377294] The Rheb GTPase-activating protein, Gigas (GIG) in complex w...
(hasEvent)[Pathway:377292] RHEB GTPase cycle [Drosophila melanogaster]
(precedingEvent)[Reaction:377363] GIG:TSC1 complex dissociates from RHEB:GDP complex [Drosophila melanogaster]
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