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Details on Person PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Class:IdLiteratureReference:377264
_displayNamePRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
_timestamp2008-09-12 10:27:22
author[Person:377021] Sancak, Y
[Person:377234] Thoreen, CC
[Person:377201] Peterson, TR
[Person:377409] Lindquist, RA
[Person:377195] Kang, SA
[Person:377441] Spooner, E
[Person:200243] Carr, SA
[Person:202096] Sabatini, DM
created[InstanceEdit:377173] Williams, MG, 2008-09-12 10:01:25
journalMol Cell
pages903-15
pubMedIdentifier17386266
titlePRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
volume25
year2007
(literatureReference)[Summation:166182] One of the two functional complexes formed by mTOR kinase is...
[Summation:376995]

AKT1 phosphorylates AKT1S1 (PRAS40, Proline Rich Akt Subs...
[Summation:381836] Activated AMPK (phosphorylated on the alpha subunit and with...
[Summation:5672784] AKT1S1 (PRAS40, proline-rich AKT/PKB substrate 40 kDa) is an...
[Reaction:376976] Activated AKT1 phosphorylates L [Drosophila melanogaster]
[Reaction:377012] Phosphorylated L dissociates from activated TOR [Drosophila melanogaster]
[Reaction:377186] Activated AKT phosphorylates AKT1S1 (PRAS40) [Homo sapiens]
[Reaction:377327] Activated TOR phosphorylates L [Drosophila melanogaster]

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