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Details on Person sFRP binds WNT3A and inhibits WNT:FZD binding

Class:Id	Reaction:3772441
_displayName	sFRP binds WNT3A and inhibits WNT:FZD binding
_doRelease	TRUE
_timestamp	2016-10-05 16:24:57
authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:3772440] Rothfels, K, 2013-06-24
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
inferredFrom	[Reaction:3772439] sFrp binds Wnt3a and inhibits WNT-FZD binding [Homo sapiens]
input	[DefinedSet:3772405] sFRP [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3247784] N4GlycoAsn-PalmS WNT3A [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3772376] Wnt3a binds to several sFRPs in the nanomolar range [LiteratureReference:3772359] Secreted antagonists of the Wnt signalling pathway [LiteratureReference:3772326] Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease [LiteratureReference:3772350] Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling [LiteratureReference:3772356] SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor
modified	[InstanceEdit:3774886] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518492] Rothfels, K, 2013-09-03 [InstanceEdit:4655213] Rothfels, K, 2013-10-02 [InstanceEdit:5097365] Rothfels, K, 2013-11-11 [InstanceEdit:5146749] Rothfels, K, 2013-11-18 [InstanceEdit:5251692] Rothfels, K, 2014-02-04 [InstanceEdit:5323653] Rothfels, K, 2014-02-15 [InstanceEdit:5576974] Rothfels, Karen, 2014-05-27 [InstanceEdit:8941686] Rothfels, Karen, 2016-10-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	sFRP binds WNT3A and inhibits WNT:FZD binding
output	[Complex:3772418] WNT3A:sFRP [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:3247843] secretion of WNT ligands [Homo sapiens] [BlackBoxEvent:3247844] WNT ligands traffic to the plasma membrane [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644674] R-HSA-3772441.3
summation	[Summation:3772442] Mammalian genomes encode 5 secreted Frizzled related protein...
(hasEvent)	[Pathway:3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists [Homo sapiens]
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