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Details on Person DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

Class:Id	Reaction:3772436
_displayName	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2
_doRelease	TRUE
_timestamp	2014-11-20 02:42:07
authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:3772432] 1-phosphatidylinositol-4-phosphate 5-kinase activity of ppDVL:PIP5K1B [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3772437] Rothfels, K, 2013-06-24
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:392417] PI4P [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:3772379] Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation [LiteratureReference:2130277] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation [LiteratureReference:208391] Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP [LiteratureReference:3772354] Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl
modified	[InstanceEdit:3774841] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518434] Rothfels, K, 2013-09-03 [InstanceEdit:4655151] Rothfels, K, 2013-10-02 [InstanceEdit:5097266] Rothfels, K, 2013-11-11 [InstanceEdit:5146677] Rothfels, K, 2013-11-18 [InstanceEdit:5228710] Rothfels, K, 2014-01-14 [InstanceEdit:5251592] Rothfels, K, 2014-02-04 [InstanceEdit:5323571] Rothfels, K, 2014-02-15 [InstanceEdit:5333073] Rothfels, K, 2014-02-18 [InstanceEdit:5576913] Rothfels, Karen, 2014-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
precedingEvent	[Reaction:3772434] Phosphorylated DVL recruits PIP5K1B to the plasma membrane [Homo sapiens] [Reaction:3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644612] R-HSA-3772436.2
summation	[Summation:3772431] Stimulation of the WNT pathway controls the activity of PIP5...
(hasEvent)	[Pathway:201688] WNT mediated activation of DVL [Homo sapiens]
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