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Details on Person PK61C further phosphorylates and fully activates AKT1

Class:IdReaction:377142
_displayNamePK61C further phosphorylates and fully activates AKT1
_doReleaseFALSE
_timestamp2017-06-27 17:36:52
authored[InstanceEdit:386955] Williams, MG, 2008-09-08 16:49:12
catalystActivity[CatalystActivity:377358] protein serine/threonine kinase activity of PK61C [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:377173] Williams, MG, 2008-09-12 10:01:25
figure[Figure:376912] /figures/ADrosINRA10.jpg
input[Complex:377081] Phospho AKT1:PIP3 [plasma membrane] [Drosophila melanogaster]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:377210] 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
[LiteratureReference:377372] PDK1 regulates growth through Akt and S6K in Drosophila
modified[InstanceEdit:386961] Williams, MG, 2008-11-27 15:11:43
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
namePK61C further phosphorylates and fully activates AKT1
output[Complex:377122] Phospho (2 sites) AKT1:PIP3 [plasma membrane] [Drosophila melanogaster]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8896766] R-DME-377142.1
summation[Summation:377249] 3-phosphoinositide-dependent protein kinase 1 (PK61C) phosph...
(hasEvent)[Pathway:377038] Regulation of AKT1 [Drosophila melanogaster]
(precedingEvent)[Reaction:376976] Activated AKT1 phosphorylates L [Drosophila melanogaster]
[Reaction:377045] PP2A dephosphorylates AKT1 [Drosophila melanogaster]
[Reaction:377238] Activated AKT1 phosphorylates GIG which dissociates from TSC1 [Drosophila melanogaster]
[Reaction:377302] Activated AKT1 phosphorylates FOXO [Drosophila melanogaster]
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No pathways have been reviewed or authored by PK61C further phosphorylates and fully activates AKT1 (377142)