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Details on Person TSC1 binds to GIG and forms a complex

Class:Id	Reaction:377048
_displayName	TSC1 binds to GIG and forms a complex
_doRelease	FALSE
_timestamp	2017-06-27 17:38:43
authored	[InstanceEdit:386955] Williams, MG, 2008-09-08 16:49:12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:377173] Williams, MG, 2008-09-12 10:01:25
figure	[Figure:376923] /figures/ADrosINRA44.jpg
input	[EntityWithAccessionedSequence:110482] GIG [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:110480] TSC1 [cytosol] [Drosophila melanogaster]
literatureReference	[LiteratureReference:377136] The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation [LiteratureReference:110487] Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. [LiteratureReference:377356] TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
modified	[InstanceEdit:386963] Williams, MG, 2008-11-27 15:33:38 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
name	TSC1 binds to GIG and forms a complex
output	[Complex:377377] GIG:TSC1 [cytosol] [Drosophila melanogaster]
precedingEvent	[Reaction:377238] Activated AKT1 phosphorylates GIG which dissociates from TSC1 [Drosophila melanogaster] [Reaction:377048] TSC1 binds to GIG and forms a complex [Drosophila melanogaster] [Reaction:377142] PK61C further phosphorylates and fully activates AKT1 [Drosophila melanogaster] [Reaction:377363] GIG:TSC1 complex dissociates from RHEB:GDP complex [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8881211] R-DME-377048.1
summation	[Summation:377402] The Tuberous Sclerosis Complex is a heterodimer formed from ...
(hasEvent)	[Pathway:377104] Regulation of GIG:TSC1 complex [Drosophila melanogaster]
(precedingEvent)	[Reaction:377144] RHEB:GTP complex binds to GIG:TSC1 complex [Drosophila melanogaster] [Reaction:377238] Activated AKT1 phosphorylates GIG which dissociates from TSC1 [Drosophila melanogaster] [Reaction:377371] GIG:TSC1 complex binds to RICTOR [Drosophila melanogaster]
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No pathways have been reviewed or authored by TSC1 binds to GIG and forms a complex (377048)