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Details on Person Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

Class:Id	LiteratureReference:377025
_displayName	Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
_timestamp	2008-09-12 10:24:20
author	[Person:68475] Li, Yun [Person:165677] Inoki, K [Person:111055] Guan, KL
created	[InstanceEdit:377173] Williams, MG, 2008-09-12 10:01:25
journal	Mol Cell Biol
pages	7965-75
pubMedIdentifier	15340059
title	Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
volume	24
year	2004
(literatureReference)	[RegulationReference:9647720] Positive regulation by 'v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP:mTORC1:RHEB:GTP:TSC [lysosomal membrane]' Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb [Reaction:377232] TSC2:TSC1 complex dissociates from Rheb:GDP complex [Homo sapiens] [Reaction:377353] RHEB:GTP complex is hydrolysed by GIG:TSC1 complex [Drosophila melanogaster] [Reaction:377373] Rheb:GTP complex binds to TSC2:TSC1 complex [Homo sapiens] [Reaction:9646464] RHEB:GTP hydrolyzes GTP [Homo sapiens]
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