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Details on Person HDAC1:2-containing complex deacetylate histones

Class:Id	Reaction:3769447
_displayName	HDAC1:2-containing complex deacetylate histones
_doRelease	TRUE
_timestamp	2020-06-15 13:16:43
authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:4657003] histone deacetylase activity of HDAC1:2-containing complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3769448] Jupe, S, 2013-06-21
edited	[InstanceEdit:3214866] Jupe, S, 2013-03-12
input	[Complex:4663858] Acetylated core histone octamer [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:4657001] Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation [LiteratureReference:3731038] Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex [LiteratureReference:3731052] SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex [LiteratureReference:3700790] NuRD and SIN3 histone deacetylase complexes in development [LiteratureReference:3731018] Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex [LiteratureReference:3769446] Identification and characterization of three new components of the mSin3A corepressor complex [LiteratureReference:3730996] The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities [LiteratureReference:480595] CoREST: a functional corepressor required for regulation of neural-specific gene expression [LiteratureReference:996762] A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes
modified	[InstanceEdit:3769453] Jupe, S, 2013-06-21 [InstanceEdit:4657005] Jupe, S, 2013-10-04 [InstanceEdit:4663824] Jupe, S, 2013-10-07 [InstanceEdit:4755541] Jupe, S, 2013-10-25 [InstanceEdit:5084126] Jupe, S, 2013-11-08 [InstanceEdit:5246548] Jupe, S, 2014-01-22 [InstanceEdit:5422999] Jupe, Steve, 2014-05-08 [InstanceEdit:5566519] Jupe, Steve, 2014-05-23 [InstanceEdit:9691330] Jassal, Bijay, 2020-06-11 [InstanceEdit:9691412] Jassal, Bijay, 2020-06-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HDAC1:2-containing complex deacetylate histones
output	[Complex:4657034] Core histone octamer [nucleoplasm] [Homo sapiens] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm] [SimpleEntity:5566518] acetate [nucleoplasm]
regulatedBy	[NegativeRegulation:9691329] Negative regulation by 'HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm]'
regulationReference	[RegulationReference:9691331] Negative regulation by 'HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm]' Histone deacetylase inhibitors: current status and overview of recent clinical trials
releaseDate	2014-06-10
reviewed	[InstanceEdit:5423007] Yang, Xiang-Jiao, 2014-05-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645095] R-HSA-3769447.3
summation	[Summation:3769451] HDAC1 and HDAC2 interact to form the catalytic core of sever...
(hasEvent)	[Pathway:3214815] HDACs deacetylate histones [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776768] Update Tracker - [Reaction:3769447] HDAC1:2-containing complex deacetylate histones - v74:[addRegulator]
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No pathways have been reviewed or authored by HDAC1:2-containing complex deacetylate histones (3769447)