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Details on Person DKK and KRM bind LRP5/6

Class:Id	Reaction:3769401
_displayName	DKK and KRM bind LRP5/6
_doRelease	TRUE
_timestamp	2014-11-20 02:53:35
authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:3769400] Rothfels, K, 2013-06-19
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input	[CandidateSet:3769325] DKK [extracellular region] [Homo sapiens] [CandidateSet:3769333] KRM1/2 [plasma membrane] [Homo sapiens] [CandidateSet:201719] LRP5/6 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3769240] Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow [LiteratureReference:1226055] Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6 [LiteratureReference:3769236] LDL-receptor-related protein 6 is a receptor for Dickkopf proteins [LiteratureReference:3769229] Function and biological roles of the Dickkopf family of Wnt modulators [LiteratureReference:3769250] Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 [LiteratureReference:3769268] Wnt antagonists bind through a short peptide to the first ?-propeller domain of LRP5/6 [LiteratureReference:3769256] Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling [LiteratureReference:3769258] Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6 [LiteratureReference:3769231] Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling [LiteratureReference:3769233] Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling [LiteratureReference:3769208] A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor [LiteratureReference:3769224] Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 [LiteratureReference:3769216] Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism [LiteratureReference:5323456] Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins [LiteratureReference:5323444] Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling [LiteratureReference:5323459] Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled
modified	[InstanceEdit:3774839] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518432] Rothfels, K, 2013-09-03 [InstanceEdit:4655147] Rothfels, K, 2013-10-02 [InstanceEdit:5097261] Rothfels, K, 2013-11-11 [InstanceEdit:5146745] Rothfels, K, 2013-11-18 [InstanceEdit:5251588] Rothfels, K, 2014-02-04 [InstanceEdit:5323565] Rothfels, K, 2014-02-15 [InstanceEdit:5576909] Rothfels, Karen, 2014-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DKK and KRM bind LRP5/6
output	[Complex:3769399] KRM:DKK:LRP5/6 [plasma membrane] [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645054] R-HSA-3769401.2
summation	[Summation:3769371] DKK1, 2 and 4 are secreted antagonists of WNT signaling that...
(hasEvent)	[Pathway:3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists [Homo sapiens]
(normalReaction)	[FailedReaction:5339711] misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5368586] DKK promotes clathrin-dependent internalization of LRP6 [Homo sapiens]
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No pathways have been reviewed or authored by DKK and KRM bind LRP5/6 (3769401)