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Details on Person SOST binds LRP5/6

Class:IdReaction:3769397
_displayNameSOST binds LRP5/6
_doReleaseTRUE
_timestamp2014-11-20 02:56:41
authored[InstanceEdit:3640727] Rothfels, K, 2013-05-29
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:3769396] Rothfels, K, 2013-06-19
edited[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input[CandidateSet:201719] LRP5/6 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:3769322] SOST [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3769252] SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
[LiteratureReference:3769254] Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
[LiteratureReference:3769217] Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation
modified[InstanceEdit:3774855] Rothfels, K, 2013-06-25
[InstanceEdit:4416357] Rothfels, K, 2013-08-25
[InstanceEdit:4518457] Rothfels, K, 2013-09-03
[InstanceEdit:4655165] Rothfels, K, 2013-10-02
[InstanceEdit:5097299] Rothfels, K, 2013-11-11
[InstanceEdit:5146746] Rothfels, K, 2013-11-18
[InstanceEdit:5251620] Rothfels, K, 2014-02-04
[InstanceEdit:5323591] Rothfels, K, 2014-02-15
[InstanceEdit:5576927] Rothfels, Karen, 2014-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSOST binds LRP5/6
output[Complex:3769334] SOST:LRP5/6 [plasma membrane] [Homo sapiens]
releaseDate2014-03-12
reviewed[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5645166] R-HSA-3769397.2
summation[Summation:3769384] SOST is a secreted antagonist of WNT signaling that acts by ...
(hasEvent)[Pathway:3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists [Homo sapiens]
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No pathways have been reviewed or authored by SOST binds LRP5/6 (3769397)