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Details on Person Although it is well established that stabilized beta-catenin...
| Class:Id | Summation:3769374 |
|---|---|
| _displayName | Although it is well established that stabilized beta-catenin... |
| _timestamp | 2014-01-14 15:53:00 |
| created | [InstanceEdit:3769373] Rothfels, K, 2013-06-19 |
| modified | [InstanceEdit:3772447] Rothfels, K, 2013-06-24 [InstanceEdit:4652710] Rothfels, K, 2013-10-02 [InstanceEdit:5228698] Rothfels, K, 2014-01-14 |
| text | Although it is well established that stabilized beta-catenin is translocated to the nucleus upon WNT pathway activation, the mechanisms that control beta-catenin localization are not fully elucidated. Beta-catenin has neither an NLS nor an NES, and its localization likely arises as the result of a complicated balance between shuttling and retention in both the nucleus and the cytoplasm (reviewed in MacDonald et al, 2009, Saito-Diaz et al, 2013). Nuclear entry of beta-catenin is independent of importins and RanGTPase (Fagotto et al, 1998; Yokoya et al, 1999) and beta-catenin has been suggested to interact directly with the nuclear pore complex by virtue of the structural similarity of its ARM domains to the importin-beta HEAT repeats (Kutay et al, 1997; Malik et al, 1997). Beta-catenin may also 'piggy-back' into the nucleus in complex with other proteins such as FOXM1 (Zhang et al, 2011 ) or BCL9 (Townsley et al, 2004). Once in the nucleus, interaction with TCF, BCL9 and Pygopus may function as an anchor for beta-catenin (Tolwinski and Wieschaus, 2001; Townsley et al, 2004; Krieghoff et al, 2006). Many of the components of the destruction complex, including APC and AXIN are also found in the nucleus and are thought to contribute to beta-catenin localization (Henderson and Fagotto, 2002; Cong and Varmus, 2004). Finally, recent work has revealed a role for Rac1 GTPase and Jun N-terminal kinase 2 (JNK2) in the nuclear localization of beta-catenin upon WNT pathway activation, although the mechanism for this remains to be elucidated (Wu et al, 2008). |
| (summation) | [BlackBoxEvent:201669] Beta-catenin translocates to the nucleus [Homo sapiens] |
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No pathways have been reviewed or authored by Although it is well established that stabilized beta-catenin... (3769374)
