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Details on Person WIF1 binds WNTs

Class:IdReaction:3769370
_displayNameWIF1 binds WNTs
_doReleaseTRUE
_timestamp2016-03-10 16:08:04
authored[InstanceEdit:3640727] Rothfels, K, 2013-05-29
compartment[Compartment:984] extracellular region
created[InstanceEdit:3769369] Rothfels, K, 2013-06-19
edited[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
inferredFrom
input[EntityWithAccessionedSequence:3769320] WIF1 [extracellular region] [Homo sapiens]
[DefinedSet:3769336] WIF1-binding WNTs [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3769272] Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer
[LiteratureReference:3769273] Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines
[LiteratureReference:3769269] Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
[LiteratureReference:3769263] WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
[LiteratureReference:3769259] The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog
[LiteratureReference:3769237] Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
[LiteratureReference:3769265] Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis
[LiteratureReference:3768849] A new secreted protein that binds to Wnt proteins and inhibits their activities
[LiteratureReference:3769213] Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1
modified[InstanceEdit:3774860] Rothfels, K, 2013-06-25
[InstanceEdit:4416357] Rothfels, K, 2013-08-25
[InstanceEdit:4518467] Rothfels, K, 2013-09-03
[InstanceEdit:4655176] Rothfels, K, 2013-10-02
[InstanceEdit:5097313] Rothfels, K, 2013-11-11
[InstanceEdit:5146747] Rothfels, K, 2013-11-18
[InstanceEdit:5251636] Rothfels, K, 2014-02-04
[InstanceEdit:5323615] Rothfels, K, 2014-02-15
[InstanceEdit:5576938] Rothfels, Karen, 2014-05-27
[InstanceEdit:8863828] Rothfels, Karen, 2016-03-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameWIF1 binds WNTs
output[Complex:3769337] WIF1:WNT [extracellular region] [Homo sapiens]
precedingEvent
releaseDate2014-03-12
reviewed[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644479] R-HSA-3769370.3
summation[Summation:3769368] WNT Inhibitory factor 1 (WIF1) is a secreted antagonist of W...
(hasEvent)[Pathway:3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists [Homo sapiens]
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