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Details on Person The SLC25A11 transport protein in the inner mitochondrial me...
| Class:Id | Summation:376853 |
|---|---|
| _displayName | The SLC25A11 transport protein in the inner mitochondrial me... |
| _timestamp | 2023-12-27 09:51:37 |
| created | [InstanceEdit:376857] D'Eustachio, P, 2008-09-09 21:21:16 |
| modified | [InstanceEdit:376863] D'Eustachio, P, 2008-09-09 21:21:29 [InstanceEdit:9815402] D'Eustachio, Peter, 2022-08-17 [InstanceEdit:9856885] Stephan, Ralf, 2023-12-27 |
| text | The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial alpha-ketoglutarate (2OG, 2-oxoglutarate) and cytosolic malate (MAL) (Booty et al., 2015; Kabe et al. 2006). Kinetic details were also inferred from studies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996). Mutations in SLC25A11 can cause adult-onset development of paragangliomas (PGL6, MIM:618464; Buffet et al., 2018). |
| (summation) | [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] |
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No pathways have been reviewed or authored by The SLC25A11 transport protein in the inner mitochondrial me... (376853)
