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Details on Person Trio family RhoGEFs activate RhoA

Class:Id	Reaction:376148
_displayName	Trio family RhoGEFs activate RhoA
_timestamp	2016-07-15 23:50:09
authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:376118] guanyl-nucleotide exchange factor activity of TRIO family RhoGEFs [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:376150] Garapati, P V, 2008-09-04 23:27:04
input	[Complex:351011] RHOA:GDP:Mg2+ [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol] [Complex:400608] G-protein alpha (q/11):Trio family RhoGEFs [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:375917] The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain
modified	[InstanceEdit:416327] Jupe, S, 2009-03-25 16:47:58 [InstanceEdit:416349] Jupe, S, 2009-03-26 09:43:54 [InstanceEdit:416474] Jupe, S, 2009-03-27 12:35:29 [InstanceEdit:420853] Jassal, Bijay, 2009-05-14 [InstanceEdit:425539] Jupe, S, 2009-06-05 [InstanceEdit:427714] Jupe, S, 2009-06-23 [InstanceEdit:427715] Jupe, S, 2009-06-23 [InstanceEdit:435383] Jupe, S, 2009-09-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Trio family RhoGEFs activate RhoA
output	[SimpleEntity:29420] GDP [cytosol] [Complex:416326] G alpha (q):Trio family RhoGEF:RhoA(Mg cofactor):GTP [cytosol] [Homo sapiens]
precedingEvent	[Reaction:400586] G alpha (q) binds to Trio family RhoGEFs [Homo sapiens] [Reaction:418576] Dissociation of the P2Y purinoceptor 1:Gq complex [Homo sapiens] [Reaction:397835] Thrombin-activated PARs:Gq (active) dissociate [Homo sapiens] [Reaction:428752] Dissociation of the TP:Gq complex [Homo sapiens] [Reaction:749452] The Ligand:GPCR:Gq complex dissociates [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8913038] R-HSA-376148.1
summation	[Summation:375938] The Trio family of RhoA guanine nucleotide exchange factors ...
(hasEvent)	[Pathway:376177] TRIO interactions [Homo sapiens] [Pathway:416476] G alpha (q) signalling events [Homo sapiens]
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No pathways have been reviewed or authored by Trio family RhoGEFs activate RhoA (376148)