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Details on Person The ROBO1 receptor regulates Rho GTPase activity through a l...
| Class:Id | Summation:375963 |
|---|---|
| _displayName | The ROBO1 receptor regulates Rho GTPase activity through a l... |
| _timestamp | 2017-06-28 17:45:33 |
| created | [InstanceEdit:375942] Garapati, P V, 2008-09-04 22:58:49 |
| literatureReference | [LiteratureReference:375968] Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway |
| modified | [InstanceEdit:428398] Garapati, P V, 2009-07-06 [InstanceEdit:428832] Garapati, P V, 2009-07-10 [InstanceEdit:9010156] Orlic-Milacic, Marija, 2017-06-26 [InstanceEdit:9010897] Orlic-Milacic, Marija, 2017-06-28 |
| text | The ROBO1 receptor regulates Rho GTPase activity through a ligand-dependent association with members of a GAP protein family called SRGAPs (SLIT-ROBO GAPs), SRGAP1, SRGAP2 and SRGAP3 (Wong et al. 2001, Bacon et al. 2011). Extracellular interaction between SLIT and ROBO increases the intracellular interaction between the CC3 motif of ROBO1 and the SH3 motif of the SRGAPs (Wong et al. 2001). |
| (summation) | [Reaction:376145] SRGAP binds ROBO1:SLIT2 [Homo sapiens] |
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No pathways have been reviewed or authored by The ROBO1 receptor regulates Rho GTPase activity through a l... (375963)
