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Details on Person Netrins are secreted proteins that play a crucial role in ne...
| Class:Id | Summation:375907 |
|---|---|
| _displayName | Netrins are secreted proteins that play a crucial role in ne... |
| _timestamp | 2010-05-06 12:49:06 |
| created | [InstanceEdit:375910] Garapati, P V, 2008-09-04 22:55:57 |
| modified | [InstanceEdit:418768] Garapati, P V, 2009-04-27 08:55:36 [InstanceEdit:624279] Garapati, P V, 2010-04-26 [InstanceEdit:686115] Garapati, P V, 2010-05-06 |
| text | Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion. |
| (summation) | [Pathway:373752] Netrin-1 signaling [Homo sapiens] |
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No pathways have been reviewed or authored by Netrins are secreted proteins that play a crucial role in ne... (375907)
