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Details on Person LAR is a transmembrane protein tyrosine phosphatase (PTPase)...
| Class:Id | Summation:375879 |
|---|---|
| _displayName | LAR is a transmembrane protein tyrosine phosphatase (PTPase)... |
| _timestamp | 2008-09-04 22:55:33 |
| created | [InstanceEdit:375895] Garapati, P V, 2008-09-04 22:55:17 |
| literatureReference | [LiteratureReference:375880] The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains |
| text | LAR is a transmembrane protein tyrosine phosphatase (PTPase) comprised of cell adhesion-like extracellular regions and two intracellular PTPase domains. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. It’s not clear whether trio is a substrate for LAR, but rather forms a complex with LAR. Trio in conjunction with LAR plays a key role in coordinating the cell-matrix interactions and cytoskeleton rearrangements involved in cell movement. |
| (summation) | [Reaction:376147] Trio binds LAR PTPase [Homo sapiens] |
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No pathways have been reviewed or authored by LAR is a transmembrane protein tyrosine phosphatase (PTPase)... (375879)
