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Details on Person DSCAM (Down syndrome cell adhesion molecule) is one of the m...
| Class:Id | Summation:375867 |
|---|---|
| _displayName | DSCAM (Down syndrome cell adhesion molecule) is one of the m... |
| _timestamp | 2010-11-09 15:36:55 |
| created | [InstanceEdit:375855] Garapati, P V, 2008-09-04 22:54:28 |
| literatureReference | [LiteratureReference:375866] DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1 [LiteratureReference:375872] Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion |
| modified | [InstanceEdit:451376] Garapati, P V, 2010-01-05 [InstanceEdit:629648] Garapati, P V, 2010-04-28 [InstanceEdit:631249] Garapati, P V, 2010-04-28 [InstanceEdit:631650] Garapati, P V, 2010-04-29 [InstanceEdit:1004529] Garapati, P V, 2010-11-09 |
| text | DSCAM (Down syndrome cell adhesion molecule) is one of the members of the Ig superfamily CAMs with a domain architecture comprising 10 Ig domains, 6 fibronectin type III (FN) repeats, a single transmembrane and a C terminal cytoplasmic domain. DSCAM is implicated in Down syndrome (DS) due to the chromosomal location of the DSCAM gene, but no evidence supports a direct involvement of DSCAM with DS. It likely functions as a cell surface receptor mediating axon pathfinding. Besides these important implications, little is known about the physiological function or the molecular mechanism of DSCAM signal transduction in mammalian systems. A closely related DSCAM paralogue Down syndrome cell adhesion moleculelike protein 1 (DSCAML1) is present in humans. Both these proteins are involved in homophilic intercellular interactions. |
| (summation) | [Pathway:376172] DSCAM interactions [Homo sapiens] |
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