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Details on Person DSCAM and DSCAML1 proteins are involved in homophilic interc...
| Class:Id | Summation:375847 |
|---|---|
| _displayName | DSCAM and DSCAML1 proteins are involved in homophilic interc... |
| _timestamp | 2010-11-09 15:36:59 |
| created | [InstanceEdit:375855] Garapati, P V, 2008-09-04 22:54:28 |
| literatureReference | [LiteratureReference:375872] Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion |
| modified | [InstanceEdit:451376] Garapati, P V, 2010-01-05 [InstanceEdit:629649] Garapati, P V, 2010-04-28 [InstanceEdit:631249] Garapati, P V, 2010-04-28 [InstanceEdit:1004529] Garapati, P V, 2010-11-09 |
| text | DSCAM and DSCAML1 proteins are involved in homophilic intercellular interactions and these recognition events may play a role in neural connectivity. Recent studies in mouse demonstrate that DSCAM is selectively expressed in subclasses of cells and suggest that it uses homophilic repulsion to simultaneously promote both self avoidance (an essential developmental mechanism that allows axonal and dendrite processes to uniformly cover their synaptic fields) and tiling (ensures that the receptive fields of neurons from the same class do not overlap with one another) (Fuerst et al. 2008). |
| (summation) | [Reaction:376122] DSCAM/DSCAML1 homodimerization [Homo sapiens] [Reaction:376127] DSCAML1 homodimerization [Homo sapiens] |
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No pathways have been reviewed or authored by DSCAM and DSCAML1 proteins are involved in homophilic interc... (375847)
