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Details on Person SLC7A1 (CAT-1)-mediated uptake of cationic amino acids

Class:Id	Reaction:375776
_displayName	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
_doRelease	TRUE
_timestamp	2025-08-14 07:45:43
authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:375796] amino acid transmembrane transporter activity of SLC7A1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:375778] D'Eustachio, P, 2008-09-04 22:11:07
crossReference	[DatabaseIdentifier:9960040] RHEA:32145 [DatabaseIdentifier:9960041] RHEA:70937 [DatabaseIdentifier:9960039] RHEA:71201
edited	[InstanceEdit:377486] D'Eustachio, P, 2008-09-12 21:44:24
input	[CandidateSet:375765] L-Arg, L-Lys, L-Orn [extracellular region]
literatureReference	[LiteratureReference:352222] Amino acid transport across mammalian intestinal and renal epithelia [LiteratureReference:375761] Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties [LiteratureReference:375780] Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1 [LiteratureReference:375767] Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes
modified	[InstanceEdit:376423] D'Eustachio, P, 2008-09-06 21:21:04 [InstanceEdit:377487] D'Eustachio, P, 2008-09-12 21:45:58 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9960042] Stephan, Ralf, 2025-07-06 [InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
name	SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
negativePrecedingEvent	[NegativePrecedingEvent:9963417] Futile Cycle: SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [NegativePrecedingEvent:9963425] Futile Cycle: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
output	[CandidateSet:375781] L-Arg, L-Lys, L-Orn [cytosol]
releaseDate	2008-09-30
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:377974] R-HSA-375776.3
summation	[Summation:375787] SLC7A1 mediates the uptake of cationic amino acids across th...
(hasEvent)	[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963387] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963416] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids [NegativePrecedingEvent:9963597] Futile Cycle: SLC7A1 (CAT-1)-mediated uptake of cationic amino acids
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