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Details on Person SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol

Class:IdReaction:375473
_displayNameSLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
_doReleaseTRUE
_timestamp2025-08-14 07:45:33
authored[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity[CatalystActivity:375470] amino acid transmembrane transporter activity of SLC6A19 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:375485] D'Eustachio, P, 2008-08-29 20:22:39
crossReference[DatabaseIdentifier:9956823] RHEA:29265
[DatabaseIdentifier:9956829] RHEA:29269
[DatabaseIdentifier:9956828] RHEA:29277
[DatabaseIdentifier:9956846] RHEA:29285
[DatabaseIdentifier:9956843] RHEA:29577
[DatabaseIdentifier:9956818] RHEA:68234
[DatabaseIdentifier:9956842] RHEA:68241
edited[InstanceEdit:377486] D'Eustachio, P, 2008-09-12 21:44:24
input[DefinedSet:375458] neutral amino acids [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
literatureReference[LiteratureReference:375453] Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19
[LiteratureReference:375462] Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
modified[InstanceEdit:375492] D'Eustachio, P, 2008-08-29 20:22:58
[InstanceEdit:376423] D'Eustachio, P, 2008-09-06 21:21:04
[InstanceEdit:377487] D'Eustachio, P, 2008-09-12 21:45:58
[InstanceEdit:5659745] Jassal, Bijay, 2014-12-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9956847] Stephan, Ralf, 2025-06-14
[InstanceEdit:9963210] Stephan, Ralf, 2025-08-13
[InstanceEdit:9963282] Stephan, Ralf, 2025-08-14
[InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
nameSLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
SLC6A19-mediated uptake of neutral amino acids
negativePrecedingEvent[NegativePrecedingEvent:9963217] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963223] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
[NegativePrecedingEvent:9963291] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
[NegativePrecedingEvent:9963281] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine
[NegativePrecedingEvent:9963284] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
[NegativePrecedingEvent:9963288] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
[NegativePrecedingEvent:9963389] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
output[DefinedSet:375481] neutral amino acids [cytosol]
[SimpleEntity:83910] Na+ [cytosol]
releaseDate2008-09-30
reviewed[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:377967] R-HSA-375473.3
summation[Summation:375461] SLC6A19 mediates the uptake of neutral amino acids across th...
(hasEvent)[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
[Pathway:442660] SLC-mediated transport of neurotransmitters [Homo sapiens]
(normalReaction)[FailedReaction:5659734] Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol [Homo sapiens]
(precedingEvent)[Reaction:428625] Vesicular inhibitory amino acid transport [Homo sapiens]
[NegativePrecedingEvent:9963381] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963391] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963392] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963396] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963403] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963406] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963407] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
(updatedInstance)[_UpdateTracker:9784048] Update Tracker - [Reaction:375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - v54:[modifyText]
[_UpdateTracker:9785099] Update Tracker - [Reaction:375473] SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - v52:[modifyText]
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