Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Bombesin-like receptors are widely distributed in the CNS as...

Class:IdSummation:375391
_displayNameBombesin-like receptors are widely distributed in the CNS as...
_timestamp2010-09-17 12:49:43
created[InstanceEdit:375386] Jassal, Bijay, 2008-08-26
literatureReference[LiteratureReference:375372] Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin
[LiteratureReference:375381] Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs
modified[InstanceEdit:375397] Jassal, Bijay, 2008-08-26
[InstanceEdit:964776] Jupe, S, 2010-09-17
textBombesin-like receptors are widely distributed in the CNS as well as in the GI tract where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behaviour through the binding of bombesin-like peptides. They include gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R) (Corjay MH et al, 1991) and bombesin-like receptor-3 (BRS-3) (Fathi Z et al, 1993). BRS-3 binds bombesin peptides with low affinity and is often classed as an orphan receptor. There are two homologues of bombesin-like peptides; Gastrin-releasing peptide (GRP) (Sausville EA et al, 1986) and Neuromedin-B (NMB) (Krane IM et al, 1988). GRP regulates gastric acid secretion and motor function and is a negative feedback operator regulating fear. NMB is involved in the regulation of many functions such as cell growth, body temperature and blood pressure and glucose levels.
(summation)[Reaction:375384] Bombesin-like receptors bind bombesin homologues [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Bombesin-like receptors are widely distributed in the CNS as... (375391)
Follow Reactome