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Details on Person UniProt:Q9HCD5 NCOA5
| Class:Id | ReferenceGeneProduct:375222 |
|---|---|
| _chainChangeLog | chain:1-579 added on Fri February 6 2015 |
| _displayName | UniProt:Q9HCD5 NCOA5 |
| _timestamp | 2024-11-03 19:47:16 |
| chain | chain:1-579 |
| checksum | D2ADCCEBEE566A91 |
| comment | FUNCTION Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).SUBUNIT Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.INTERACTION Widely expressed.DOMAIN Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors. |
| created | [InstanceEdit:375211] Caudy, M, 2008-08-16 03:57:25 |
| description | recommendedName: Nuclear receptor coactivator 5 shortName: NCoA-5 alternativeName: Coactivator independent of AF-2 shortName: CIA |
| geneName | NCOA5 KIAA1637 |
| identifier | Q9HCD5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NCOA5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990267] ENSEMBL:ENSG00000124160 NCOA5 [Homo sapiens] |
| secondaryIdentifier | NCOA5_HUMAN B2RTV9 E1P5R0 Q6HA99 Q9H1F2 Q9H2T2 Q9H4Y9 |
| sequenceLength | 579 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:376400] NCOA5 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9HCD5 NCOA5 (375222)
