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Details on Person UniProt:Q14686 NCOA6
| Class:Id | ReferenceGeneProduct:375216 |
|---|---|
| _chainChangeLog | chain:1-2063 added on Fri February 6 2015 |
| _displayName | UniProt:Q14686 NCOA6 |
| _timestamp | 2024-11-03 19:47:16 |
| chain | chain:1-2063 |
| checksum | 73219502F5138427 |
| comment | FUNCTION Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.SUBUNIT Monomer and homodimer. Interacts with RBM39 (By similarity). Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferases EP300 and CREBBP, and with the methyltransferases NCOA6IP and PRMT2/HRMT1L1. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors.INTERACTION Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.DOMAIN Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors.PTM Phosphorylated by PRKDC.PTM Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2.MISCELLANEOUS Frequently amplified or overexpressed in colon, breast and lung cancers.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:375211] Caudy, M, 2008-08-16 03:57:25 |
| description | recommendedName: Nuclear receptor coactivator 6 alternativeName: Activating signal cointegrator 2 shortName: ASC-2 alternativeName: Amplified in breast cancer protein 3 alternativeName: Cancer-amplified transcriptional coactivator ASC-2 alternativeName: Nuclear receptor coactivator RAP250 shortName: NRC RAP250 alternativeName: Nuclear receptor-activating protein, 250 kDa alternativeName: Peroxisome proliferator-activated receptor-interacting protein shortName: PPAR-interacting protein shortName: PRIP alternativeName: Thyroid hormone receptor-binding protein |
| geneName | NCOA6 AIB3 KIAA0181 RAP250 TRBP |
| identifier | Q14686 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Activator Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NCOA6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991994] ENSEMBL:ENSG00000198646 NCOA6 [Homo sapiens] |
| secondaryIdentifier | NCOA6_HUMAN A6NLF1 B2RMN5 E1P5P7 Q9NTZ9 Q9UH74 Q9UK86 |
| sequenceLength | 2063 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:376414] NCOA6 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14686 NCOA6 (375216)
