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Details on Person UniProt:Q9Y6Q9-2 NCOA3
| Class:Id | ReferenceIsoform:375214 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-1424 added on Fri February 6 2015;initiator methionine:1 for 375214 removed on Fri Nov 03 2023;initiator methionine: for 375214 added on Fri Nov 03 2023;initiator methionine: for 375214 removed on Fri Aug 15 2025;initiator methionine:1 for 375214 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9Y6Q9-2 NCOA3 |
| _timestamp | 2026-02-20 22:46:17 |
| chain | initiator methionine:1 chain:2-1424 |
| checksum | 732CDF0423161679 |
| comment | FUNCTION Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.CATALYTIC ACTIVITY L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)ACTIVITY REGULATION Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.SUBUNIT Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP (PubMed:11971985, PubMed:9346901). Found in a complex containing NCOA3, AR and MAK (PubMed:16951154). Interacts with ATAD2; the interaction is enhanced by estradiol (PubMed:17998543). Interacts with CARM1 (By similarity). Interacts with CASP8AP2 (PubMed:15698540). Interacts with CSNK1D (PubMed:19339517). Interacts with DDX5 (PubMed:11250900). Interacts with ESR (PubMed:9238002, PubMed:9252329, PubMed:9346901). Interacts with ESRRB; mediates the interaction between ESRRB and RNA polymerase II complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to trigger ESRRB-dependent gene activation involved in self-renewal and pluripotency (By similarity). Interacts with NFKB1 (PubMed:11094166). Interacts with NPAS2 (PubMed:14645221). Interacts with NR3C1 (PubMed:12917342). Interacts with NR4A1/Nur77 (PubMed:18690216). Interacts with NR4A3 (By similarity). Interacts with PCAF (PubMed:9346901). Interacts with PPARA (PubMed:9238002). Interacts with PSMB9 (PubMed:16957778). Interacts with RARA (PubMed:9238002, PubMed:9346901). Interacts with RXRA (PubMed:9238002, PubMed:9346901). Interacts with THRA (PubMed:9238002, PubMed:9346901). Interacts with VDR (PubMed:9238002).SUBCELLULAR LOCATION Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.DOMAIN Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).PTM Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.PTM Methylated by CARM1.PTM Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.POLYMORPHISM The length of the poly-Gln region is polymorphic in the normal population.MISCELLANEOUS NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.SIMILARITY Belongs to the SRC/p160 nuclear receptor coactivator family. |
| created | [InstanceEdit:375211] Caudy, M, 2008-08-16 03:57:25 |
| description | recommendedName: Nuclear receptor coactivator 3 shortName: NCoA-3 ecNumber: 2.3.1.48 alternativeName: ACTR alternativeName: Amplified in breast cancer 1 protein shortName: AIB-1 alternativeName: CBP-interacting protein shortName: pCIP alternativeName: Class E basic helix-loop-helix protein 42 shortName: bHLHe42 alternativeName: Receptor-associated coactivator 3 shortName: RAC-3 alternativeName: Steroid receptor coactivator protein 3 shortName: SRC-3 alternativeName: Thyroid hormone receptor activator molecule 1 shortName: TRAM-1 |
| geneName | NCOA3 AIB1 BHLHE42 RAC3 TRAM1 |
| identifier | Q9Y6Q9 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Acyltransferase Alternative splicing Cytoplasm Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NCOA3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000177] ENSEMBL:ENSG00000124151 NCOA3 [Homo sapiens] |
| secondaryIdentifier | NCOA3_HUMAN A4LAZ5 Q0VF45 Q5JYD9 Q5JYE0 Q9BR49 Q9UPC9 Q9UPG4 Q9UPG7 |
| sequenceLength | 1424 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9Y6Q9-2 |
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No pathways have been reviewed or authored by UniProt:Q9Y6Q9-2 NCOA3 (375214)
