Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Antiparallel NCAM interactions involve trans-interactions of...
| Class:Id | Summation:375041 |
|---|---|
| _displayName | Antiparallel NCAM interactions involve trans-interactions of... |
| _timestamp | 2009-09-04 08:52:12 |
| created | [InstanceEdit:375044] Garapati, P V, 2008-08-11 10:27:37 |
| literatureReference | [LiteratureReference:420316] Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion [LiteratureReference:375122] Zippers make signals: NCAM-mediated molecular interactions and signal transduction |
| modified | [InstanceEdit:391817] Garapati, P V, 2009-02-24 10:31:41 [InstanceEdit:420318] Garapati, P V, 2009-05-11 14:08:35 [InstanceEdit:420406] Garapati, P V, 2009-05-11 17:37:36 [InstanceEdit:420749] D'Eustachio, P, 2009-05-13 15:09:14 [InstanceEdit:434892] Garapati, P V, 2009-09-04 |
| text | Antiparallel NCAM interactions involve trans-interactions of NCAM molecules on opposed cell membranes. Based on structural and functional studies a 'double zipper' model has been proposed to describe these interactions. The first model - the 'flat zipper'- formed between NCAM1 cis-dimers from one cell surface interacting in trans through IgII-IgIII contacts with NCAM1 cis-dimers from another cell surface. The second model - the 'compact zipper'- is formed between NCAM1 cis-dimers from one cell surface interacting in trans through IgI-IgIII and IgII-IgII contacts with cis-dimers from another cell surface. Abrogation of cis-dimerization inhibits NCAM mediated neurite outgrowth, and cis-dimerization of NCAM1 may be a necessary prerequisite for subsequent trans-interactions. |
| (summation) | [Reaction:375161] NCAM1 trans-homophilic interaction [Homo sapiens] [Reaction:420397] NCAM1 trans-homophilic interaction [Rattus norvegicus] |
| [Change default viewing format] | |
