Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person Once vesicles are docked, primed and ready to be released fu...
| Class:Id | Summation:374910 |
|---|---|
| _displayName | Once vesicles are docked, primed and ready to be released fu... |
| _timestamp | 2008-08-05 20:33:23 |
| created | [InstanceEdit:374906] Mahajan, SS, 2008-08-05 20:29:44 |
| literatureReference | [LiteratureReference:210436] How synaptotagmin promotes membrane fusion [LiteratureReference:210379] A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis |
| text | Once vesicles are docked, primed and ready to be released fusion of the synaptic vesicle with the plasma membrane can be triggered by an influx of Ca2+ through the voltage gated Ca2+ channels (N, P/Q and R type). Ca2+ influx initiates a cascade of events in which the Ca2+ sensing protein, synaptotagmin-1 (sty-1) is central. Sty-1 promotes the membrane fusion between the synaptic vesicle and the plasma membrane by Ca2+ dependant induction of membrane curvature. Synaptotagmin competes with SNARE complex binding in a Ca2+ dependent manner thereby displacing complexin-1 and causing membrane curvature and fusion of the synaptic vesicle with the plasma membrane. The fusion is characterized by the formation of a trans SNARE complex in which SNAP 25, syntaxin and synaptobrevin along with VGLUT1, the glutamate transporter, synaptotagmin, and Rab3a either become a part of the plasma membrane or membrane delimited in the vesicular membrane. Vesicle fusion ultimately results in the release of the noradrenalin into the synaptic cleft. |
| (summation) | [Reaction:374899] Release of noradrenaline at the synapse [Homo sapiens] |
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No pathways have been reviewed or authored by Once vesicles are docked, primed and ready to be released fu... (374910)
