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Details on Person Sodium channel beta1 subunits are multifunctional, participa...

Class:IdSummation:374641
_displayNameSodium channel beta1 subunits are multifunctional, participa...
_timestamp2008-07-30 10:18:59
created[InstanceEdit:374642] Garapati, P V, 2008-07-30 10:18:58
literatureReference[LiteratureReference:374483] Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin
[LiteratureReference:374419] Contactin associates with Na+ channels and increases their functional expression
textSodium channel beta1 subunits are multifunctional, participating in channel modulation, regulation of channel cell surface expression, and cell adhesion. The beta1 Ig loop domain is essential for beta1-contactin interactions and through this interaction contactin regulates the surface expression of sodium channels.
(summation)[Reaction:374660] Contactin-1 binds Sodium channel subunit beta-1 [Homo sapiens]
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