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Details on Person CXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et ...

Class:IdSummation:374139
_displayNameCXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et ...
_timestamp2008-08-29 12:52:18
created[InstanceEdit:374171] Jassal, Bijay, 2008-07-28
literatureReference[LiteratureReference:374126] Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene
[LiteratureReference:374134] Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity
[LiteratureReference:374186] Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation
[LiteratureReference:374161] Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells
modified[InstanceEdit:374263] Jassal, Bijay, 2008-07-28
[InstanceEdit:375446] Jassal, Bijay, 2008-08-29
textCXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et al, 1995) is produced in two forms, CXCL12alpha and CXCL12beta, by alternate splicing of the same gene (De La Luz Sierra M et al, 2004). It is a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. In adult humans it plays an important role in angiogenesis by recruiting endothelial progenitor cells from the bone morrow through a CXCR4-dependent mechanism. CXCR4 (fusin) (Herzog H et al, 1993) is the receptor for CXCL12 and, like CCR5, is utilized by HIV-1 to gain entry into target cells. This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types and also on vascular endothelial cells and neuronal/nerve cells. CXCR7 (RDC-1) (Infantino S et al, 2006) is expressed in monocytes, basophils and B cells and was originally an orphan receptor.
(summation)[Reaction:374214] Receptors CXCR4 and 7 bind CXCL12 ligand [Homo sapiens]
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No pathways have been reviewed or authored by CXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et ... (374139)
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